{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:18:58Z","timestamp":1787663938990,"version":"build-2736575974"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021372","name":"Hector Stiftung","doi-asserted-by":"publisher","award":["M 2117"],"award-info":[{"award-number":["M 2117"]}],"id":[{"id":"10.13039\/501100021372","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Many childhood and adolescent cancer survivors suffer from late effects that impair quality of life and life expectancy. However, only an estimated 5% of &gt;\u200947,000 survivors in Germany receive adequate long\u2010term follow\u2010up (LTFU) care. The LE\u2010Na (Evaluation and implementation of multidisciplinary, standardized, guideline\u2010based long\u2010term follow\u2010up care for adult survivors of childhood cancer in Germany) study aims to address this care gap. Our interim analysis compares three recruitment and information pathways and provides information on the feasibility and acceptance of a guideline\u2010based psychosocial screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Over the total study period of 5\u2009years, 5000 survivors without previous LTFU care are systematically invited to specialized LTFU clinics in Germany: (1) through the German Childhood Cancer Registry (GCCR), (2) during transition from pediatric to adult care, and (3) via media presence. Longitudinal sociodemographic, medical, and psychosocial data are documented in an online database. Follow\u2010up intervals are based on therapy\u2010associated risk for late effects: annually (high risk), biannually (medium risk), or every 5\u2009years (low risk).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By the time of our interim analysis, 300 survivors with completed data documentation had been enrolled: 121 (40.3%) were recruited via GCCR invitations, 155 (51.7%) through a structured transition, and 24 (8%) via media presence. Nearly half (131\/300; 43.7%) were at high risk for late effects. Almost all (299\/300, 99.7%) completed psychosocial screening. A Distress\u2010Thermometer score of \u2265\u20095 was found in half of the participants (146\/299; 48.8%), indicating relevant psychosocial distress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Through the different recruitment methods, survivors with a high risk for late effects were particularly encouraged to accept the LTFU care offer. Integrating a psychosocial screening is feasible and confirms survivors' distress.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>DRKS identifier: DRKS00033303<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72148","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T12:56:10Z","timestamp":1785848170000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of Integrating a Standardized Psychosocial Follow\u2010Up After Childhood Cancer\u2014An Interim Analysis of the\n                    <scp>LE<\/scp>\n                    \u2010Na Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0251-3958","authenticated-orcid":false,"given":"Madelaine","family":"Sleimann","sequence":"first","affiliation":[{"name":"Department of Pediatrics University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"},{"name":"Department of Pediatric Oncology and Hematology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Balcerek","sequence":"additional","affiliation":[{"name":"Department of Oncology, Hepatology and Pneumology University Hospital Leipzig and University Cancer Center Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Calaminus","sequence":"additional","affiliation":[{"name":"Clinic for Pediatric Hematology and Oncology, Center for Pediatric and Adolescent Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina B.","family":"Schaefer","sequence":"additional","affiliation":[{"name":"Clinic for Pediatric Hematology and Oncology, Center for Pediatric and Adolescent Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Lohse","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Pediatrics and Adolescent Medicine, Department of Pediatric Hematology and Oncology University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine University Hospital Erlangen, Friedrich\u2010Alexander\u2010Universit\u00e4t Erlangen\u2010N\u00fcrnberg (FAU)  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Halbsguth","sequence":"additional","affiliation":[{"name":"Department of Medicine II, Hematology and Oncology, University Cancer Center (UCT) Frankfurt University Hospital Frankfurt, Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Puzik","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, Children's Hospital, Medical Center, Faculty of Medicine University of Freiburg  Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology With Section Pneumology, Hubertus Wald Tumor Center\u2013University Cancer Center Hamburg University Medical Center Hamburg\u2010Eppendorf (UKE)  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Faber","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, Department of Pediatrics and Adolescent Medicine University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"von Luettichau","sequence":"additional","affiliation":[{"name":"Center for Pediatrics and Adolescent Medicine, a Collaboration Between Munich Clinic and TUM University Hospital Rechts der Isar, TUM School of Medicine and Health  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"H\u00f6mberg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Asklepios Children's Hospital Sankt Augustin  Sankt Augustin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Michaelis","sequence":"additional","affiliation":[{"name":"Department I of Pediatric Hematology and Oncology University Children's Hospital T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Childhood Cancer (EpiKiK)\/German Childhood Cancer Registry (DKKR), Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Grabow","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Childhood Cancer (EpiKiK)\/German Childhood Cancer Registry (DKKR), Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inke","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institute of Medical Biometry and Statistics (IMBS), University of Luebeck, University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Neumann","sequence":"additional","affiliation":[{"name":"Section for Clinical Research IT (SKFIT) Institute of Medical Biometry and Statistics (IMBS), University of Luebeck and University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Kristin","family":"Kock\u2010Schoppenhauer","sequence":"additional","affiliation":[{"name":"Section for Clinical Research IT (SKFIT) Institute of Medical Biometry and Statistics (IMBS), University of Luebeck and University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Arendt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7047-2957","authenticated-orcid":false,"given":"Thorsten","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Baust","sequence":"additional","affiliation":[{"name":"Clinic for Pediatric Hematology and Oncology, Center for Pediatric and Adolescent Medicine University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Gebauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"},{"name":"Department of Oncology, Hepatology and Pneumology University Hospital Leipzig and University Cancer Center Leipzig  Leipzig Germany"},{"name":"Department of Hematology and Oncology University Hospital Schleswig\u2010Holstein  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3634"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00103-022-03507-0"},{"key":"e_1_2_13_4_1","volume-title":"German Childhood Cancer Registry\u2014Annual Report 2019 (1980\u20132018)","author":"Erdmann F.","year":"2020"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1275352"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0754-2362"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31610-0"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21445"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.127"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00750-6"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2006.095513"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw4892"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejon.2020.101728"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-020-00904-9"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.5552"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34215"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.1482"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14355-x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05145-8"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504200"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530970"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.03.001"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1918-0"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2009.06.019"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_13_26_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1024\/1661-4747.54.3.213","article-title":"Die Deutsche Version des NCCN Distress\u2010Thermometers: Empirische Pr\u00fcfung eines Screening\u2010Instruments zur Erfassung psychosozialer Belastung bei Krebspatienten","volume":"54","author":"Mehnert\u2010Theuerkauf A.","year":"2006","journal-title":"Zeitschrift f\u00fcr Psychiatrie, Psychologie und Psychotherapie"},{"key":"e_1_2_13_27_1","first-page":"130","article-title":"Erfassung von Psychischen Belastungsfolgen: Die Impact of Event Skala\u2010Revidierte Version (IES\u2010R). Assessment of Post\u2010Traumatic Stress Reactions: The Impact of Event Scale\u2010Revised (IES\u2010R)","volume":"44","author":"Maercker A.","year":"1998","journal-title":"Diagnostica"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw273"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5593"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2021-053127"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30659-3"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1935"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34944"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.13749"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27432"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1212"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14251"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.5870"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29736"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP-24-00815"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22875"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72148","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:25:14Z","timestamp":1787660714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cam4.72148"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72148","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72148"}}