{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:19:08Z","timestamp":1787663948979,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070781"],"award-info":[{"award-number":["32070781"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82203543"],"award-info":[{"award-number":["82203543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020MH166"],"award-info":[{"award-number":["ZR2020MH166"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH267"],"award-info":[{"award-number":["ZR2022QH267"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023LZL008"],"award-info":[{"award-number":["ZR2023LZL008"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the expression profile of IL\u20106 in patients with acute promyelocytic leukemia (APL) and its role in modulating the ability of hPMSCs to regulate the differentiation of NB4 cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Peripheral blood samples were obtained from newly diagnosed APL patients and healthy controls. IL\u20106 levels were measured using flow cytometry\u2010based (FCM) multiplex immunoassays. A co\u2010culture system of hPMSCs and NB4 cells was established. The effects of hPMSCs on ATRA\u2010induced differentiation, proliferation, and phagocytic activity of NB4 cells were evaluated by Wright\u2013Giemsa staining, FCM, CCK\u20108 assays, and phagocytosis assays. Western blot analysis was performed to investigate the signaling mechanisms by which IL\u20106 regulates CD73 expression in hPMSCs. To determine whether the regulatory effects of hPMSCs are mediated by CD73, interventions using a CD73 inhibitor and CD73\u2010knockdown hPMSCs were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>IL\u20106 levels were significantly elevated in the peripheral blood of APL patients and showed a positive correlation with both risk stratification and the severity of retinoic acid syndrome (RAS). hPMSCs enhanced ATRA\u2010induced differentiation of NB4 cells while suppressing their proliferation and phagocytic function. Moreover, inhibition or knockdown of CD73 markedly attenuated the pro\u2010differentiation effect of hPMSCs on NB4 cells. NB4 cells exhibited high surface expression of adenosine receptors. IL\u20106 was found to upregulate CD73 expression in hPMSCs through activation of the PI3K\/AKT signaling pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IL\u20106 enhances the pro\u2010differentiation capacity of hPMSCs toward NB4 cells by upregulating CD73 expression, offering a potential new strategy for the clinical treatment of APL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72149","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:21:06Z","timestamp":1785388866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>IL<\/scp>\n                    \u20106 Upregulates\n                    <scp>CD73<\/scp>\n                    in Human Placental Mesenchymal Stem Cells to Promote\n                    <scp>ATRA<\/scp>\n                    \u2010Induced\n                    <scp>NB4<\/scp>\n                    Cell Differentiation in Acute Promyelocytic Leukemia"],"prefix":"10.1002","volume":"15","author":[{"given":"Rong","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Immunology Shandong Medical and Pharmaceutical University  Yantai Shandong Province China"},{"name":"Department of Clinical Lab Yantai Yuhuangding Hospital Affiliated to Qingdao University  Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengchao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Lab Yantaishan Hospital Affiliated to Shandong Medical and Pharmaceutical University  Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Immunology Shandong Medical and Pharmaceutical University  Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2091-0696","authenticated-orcid":false,"given":"Yanchao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Immunology Shandong Medical and Pharmaceutical University  Yantai Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Immunology Shandong Medical and Pharmaceutical University  Yantai Shandong Province 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