{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:19:12Z","timestamp":1787663952170,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Resistin is a macrophage\u2010associated cytokine linked to obesity\u2010driven inflammation, a recognised risk factor for colorectal cancer. Prior studies of circulating resistin in colorectal cancer have reported inconsistent findings, largely because patients were analysed as a single group without accounting for tumour stage. Whether resistin follows a stage\u2010specific pattern across the adenoma\u2013carcinoma sequence, independent of insulin resistance and conventional tumour markers, has not been systematically examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010centre study, serum resistin levels were measured in 179 participants, including 137 patients with colorectal cancer (\n                      <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>\n                      ), 11 with colorectal adenomas and 31 healthy controls. Tumour markers and metabolic variables were analysed. Moreover, stage\u2010stratified comparisons were performed using non\u2010parametric testing and ordinal logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Circulating resistin concentrations varied significantly across diagnostic categories and tumour stage. Elevated levels were observed in adenomas and early\u2010stage CRC (stage I\u2013II; median ~7600\u2009pg\/mL), whereas significantly lower levels were detected in advanced\u2010stage disease (stage III\u2013IV; median ~2500\u2009pg\/mL;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). In multivariable ordinal regression analysis, resistin remained independently associated with tumour stage after adjustment for BMI, fasting insulin, CEA and CA19\u20109. Resistin levels were not associated with insulin resistance as measured by HOMA\u2010IR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circulating resistin shows a stage\u2010dependent association across colorectal tumorigenesis, with higher levels in premalignant and early\u2010stage disease and lower levels in advanced\u2010stage disease. These cross\u2010sectional findings are consistent with a model in which resistin reflects host inflammatory activation rather than tumour burden, although this interpretation remains hypothesis\u2010generating. This pattern may help explain previously inconsistent associations reported for resistin in colorectal cancer; however, further prospective and mechanistic studies are required to clarify its role in tumour progression and validate our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72160","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T04:35:14Z","timestamp":1786422914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage\u2010Specific Differences in Circulating Resistin From Premalignant to Advanced Colorectal Cancer: A Cross\u2010Sectional Cohort Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4354-0130","authenticated-orcid":false,"given":"Aliki Vaia","family":"Rompou","sequence":"first","affiliation":[{"name":"Agios Savvas Cancer Hospital  Athens Greece"},{"name":"Post\u2010Doctoral Candidate Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garyfalia","family":"Bletsa","sequence":"additional","affiliation":[{"name":"Research Center, Hellenic Anticancer Institute  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6835-8410","authenticated-orcid":false,"given":"Dimitris","family":"Tsakogiannis","sequence":"additional","affiliation":[{"name":"Research Center, Hellenic Anticancer Institute  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5859-7917","authenticated-orcid":false,"given":"Pantelis","family":"Vassiliu","sequence":"additional","affiliation":[{"name":"Fourth Department of Surgery, National and Kapodistrian University of Athens, School of Medicine Attikon University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0930-1657","authenticated-orcid":false,"given":"Stamatios","family":"Theocharis","sequence":"additional","affiliation":[{"name":"First Department of Pathology Medical School, National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Danias","sequence":"additional","affiliation":[{"name":"Fourth Department of Surgery, National and Kapodistrian University of Athens, School of Medicine Attikon University Hospital  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61649-9"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90186-I"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32319-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235122"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.025"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0395"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1937"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02841-3"},{"issue":"7","key":"e_1_2_12_12_1","first-page":"259","article-title":"Human Resistin: Found in Translation From Mouse to Man","volume":"22","author":"Schwartz D. R.","year":"2011","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010045"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7367485"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34830"},{"issue":"7","key":"e_1_2_12_16_1","article-title":"An Updated Review of Resistin and Colorectal Cancer","volume":"16","author":"Rompou A. V.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.2644"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2008.06.006"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.217"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa6204"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.101"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010025\u201000872\u20101"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:25:53Z","timestamp":1787660753000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cam4.72160"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72160","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72160"}}