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In later studies, we found that SLC7A1 is also highly expressed in the interstitial portion of high\u2010grade serous ovarian cancer (HGSOC), but the significance of this high expression in the interstitial remains unclear. Here, we showed the Interstitial high expression of SLC7A1 in HGSOC by immunohistochemistry. SLC7A1 enriched in cancer\u2010associated fibroblasts (CAFs) was upregulated by TGF\u2010\u03b21. Transwell assay, scratch assay, cck8 assay and cell adhesion assay showed that SLC7A1 highly expressed in CAFs promoted tumor cells invasion, migration and metastasis in\u00a0vitro. The effect of SLC7A1 on MAPK and EMT pathway proteins in ovarian cancer (OC) was verified by RNA sequencing and western blotting. Overexpression of SLC7A1 in OC is involved in MAPK\/ ERK pathway and EMT. In general, in HGSOC, CAFs overexpressing SLC7A1 supported the migration and invasion of tumor cells; SLC7A1 is highly expressed in ovarian cancer and is involved in ERK phosphorylation and EMT signaling in MAPK signaling pathway. This suggests that SLC7A1 may be a potential therapeutic target for OC metastasis.<\/jats:p>","DOI":"10.1002\/cam4.7217","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T10:39:34Z","timestamp":1715855974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["High expression of <scp>SLC7A1<\/scp> in high\u2010grade serous ovarian cancer promotes tumor progression and is involved in <scp>MAPK<\/scp>\/<scp>ERK<\/scp> pathway and <scp>EMT<\/scp>"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3044-1494","authenticated-orcid":false,"given":"Shijing","family":"You","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Affiliated Hospital of Qingdao University  Qingdao Shandong 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