{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:08Z","timestamp":1791262568632,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000210888"],"award-info":[{"award-number":["RS\u20102023\u201000210888"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated steatotic liver disease (MASLD) is a growing public health concern, particularly among young adults. While MASLD is a well\u2010established risk factor for liver\u2010related complications, growing evidence suggests an association with several extrahepatic cancers. However, data regarding cancer risk among young adults with MASLD remain limited. This study investigates the association between MASLD and cancer risk in young adults in South Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A nationwide cohort study was conducted using the Korean National Health Insurance Service database, including individuals aged 20\u201339\u2009years who underwent health screenings (2004\u20132007). Clinically diagnosed fatty liver disease was identified using ICD\u201010 code K76.0, and incident cancers were identified using ICD\u201010 malignant neoplasm codes recorded in the National Health Insurance Service claims database through 2022. Cox proportional hazards models estimated hazard ratios (HRs) for cancer risk, adjusting for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 4,094,241 participants, 254,897 (6.22%) had clinically diagnosed fatty liver disease. Clinically diagnosed fatty liver disease was significantly associated with increased all\u2010cancer incidence in both men (HR: 1.48, 95% CI 1.45\u20131.51) and women (HR: 1.23, 95% CI 1.20\u20131.27). The highest risks were observed for liver cancer (men, HR: 2.39, 95% CI 2.28\u20132.50, women, HR: 2.88, 95% CI 2.56\u20133.23), thyroid cancer (men, HR: 1.49, 95% CI 1.43\u20131.55, women, HR: 1.18, 95% CI 1.13\u20131.24). BMI\u2010based fatty liver disease (BMI &lt;\u200925\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) showed a higher liver cancer risk. Non\u2010drinkers with clinically diagnosed fatty liver disease also had increased cancer risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Clinically diagnosed fatty liver disease in young adults was associated with a higher risk of both hepatic and extrahepatic cancers. Further studies are needed to determine appropriate risk\u2010stratified prevention and surveillance strategies in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72187","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:44:51Z","timestamp":1788759891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer Risk Among Young Adults With Clinically Diagnosed Fatty Liver Disease: A Nationwide Cohort Study in South Korea"],"prefix":"10.1002","volume":"15","author":[{"given":"Sun Ju","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Big Data Strategies National Health Insurance Service (NHIS)  Wonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0365-8302","authenticated-orcid":false,"given":"Yongho","family":"Jee","sequence":"additional","affiliation":[{"name":"Advanced Biomedical Research Institute Ewha Womans University Seoul Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-6612","authenticated-orcid":false,"given":"Ho Soo","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7261-3365","authenticated-orcid":false,"given":"Hyun\u2010Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"issue":"4","key":"e_1_2_13_2_1","article-title":"NAFLD in the 21st Century: Current Knowledge Regarding Its Pathogenesis, Diagnosis and Therapeutics","volume":"12","author":"Kounatidis D.","year":"2024","journal-title":"Biomedicine"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12247634"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2021.0178"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0239"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00165-0"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2020.06.022"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15673"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00275-3"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.35511"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-324191"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.015"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad575"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl210084"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2022-003066"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15832"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01740"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1037211"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2024.0522"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.01.029"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i27.3410"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-023-03351-5"},{"key":"e_1_2_13_23_1","first-page":"S542","article-title":"Prevalence of Lean NAFLD vs Lean MAFLD Indicates a Distinct Risk of Mortality","volume":"75","author":"Semmler G.","year":"2021","journal-title":"Journal of Hepatology"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14112"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2010.09.037"},{"issue":"4","key":"e_1_2_13_26_1","first-page":"184","article-title":"Lean Nonalcoholic Steatohepatitis and Nonalcoholic Fatty Liver Disease","volume":"17","author":"Gunn N. 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