{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:51:22Z","timestamp":1791265882278,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473176"],"award-info":[{"award-number":["82473176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972213"],"award-info":[{"award-number":["81972213"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1412700"],"award-info":[{"award-number":["22ZR1412700"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ratio of red blood cell distribution width (RDW) to serum albumin (RAR) combines hematologic and nutritional information from routine blood tests and has shown potential value for prognostication in several diseases. This study aimed to evaluate the prognostic significance of preoperative RAR in patients with gastric cancer undergoing curative gastrectomy and to explore whether RAR could provide additional prognostic information beyond conventional indicators such as TNM stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study evaluated the prognostic value of preoperative RAR in patients with gastric cancer undergoing curative resection. Specifically, we aimed to (i) determine the association between RAR and clinicopathological characteristics, (ii) assess its predictive value for overall survival (OS) and disease\u2010free survival (DFS), and (iii) evaluate the complementary prognostic value of RAR beyond conventional indicators such as TNM stage and other markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective cohort study including 6988 patients with gastric cancer who underwent curative resection at a tertiary cancer center between July 2011 and December 2022. We explored associations between preoperative RAR and a range of clinicopathological characteristics. Overall survival was estimated by the Kaplan\u2013Meier method, and Cox proportional hazards models were used to assess factors influencing prognosis. The discriminative ability of RAR was evaluated using time\u2010dependent ROC analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An elevated baseline RAR was associated with older age, larger tumor dimensions, higher TNM classification, lymphatic spread, deeper tumor invasion, and the presence of vascular and perineural invasion, with poorer overall survival (OS) and disease\u2010free survival (DFS). Time\u2010dependent receiver operating characteristic analyses indicated that RAR consistently achieved higher discriminative performance than neutrophil\u2010to\u2010lymphocyte ratio (NLR), lymphocyte\u2010to\u2010monocyte ratio (LMR), and platelet\u2010to\u2010lymphocyte ratio (PLR) across follow\u2010up. However, the absolute AUC values remained modest, indicating that RAR alone has limited predictive capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RAR may facilitate postoperative risk stratification as an accessible prognostic marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72197","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:31:47Z","timestamp":1787981507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preoperative\n                    <scp>RDW<\/scp>\n                    \u2013Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3579-0829","authenticated-orcid":false,"given":"Xinhang","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Gastric Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"},{"name":"School of Basic Medical Science Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Taizhou People's Hospital  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"The Central Blood Station Taixing People's Hospital  Taixing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endoscopy Center Zhongshan Hospital, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangbai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"},{"name":"Department of Musculoskeletal Surgery Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8858-0983","authenticated-orcid":false,"given":"Mingzhe","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Gastric Surgery Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology, Shanghai Medical College Fudan University  Shanghai 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