{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:50:45Z","timestamp":1791265845953,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372210"],"award-info":[{"award-number":["81372210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Studies have demonstrated that the nervous system plays an important role in cancer progression. Nevertheless, the effect of mesenchymal stem cells (MSCs) on cancer has yielded conflicting results. In this study, we discovered that cancer\u2010derived MSCs (CA\u2010MSCs) not only exhibit the properties of neural stem cells (NSCs) but also express a significant amount of neural\u2010related products. These products include neurotrophic factors, neuropeptides, synapse\u2010related products, and axon guidance factors. These identified products exhibit similar or different expression status among human NSCs, cancer and fat\u2010derived MSCs. CA\u2010MSCs expressed more\n                    <jats:italic>BDNF<\/jats:italic>\n                    ,\n                    <jats:italic>GDNF<\/jats:italic>\n                    , and\n                    <jats:italic>NGF<\/jats:italic>\n                    than NSCs. Based on these neural\u2010related products expressed by CA\u2010MSCs, expression\u2010prognostic analysis was conducted. It revealed that the expression of\n                    <jats:italic>MDK<\/jats:italic>\n                    and\n                    <jats:italic>MANF<\/jats:italic>\n                    was higher in cancer, and the expression of\n                    <jats:italic>BDNF<\/jats:italic>\n                    ,\n                    <jats:italic>NPTX1<\/jats:italic>\n                    , and\n                    <jats:italic>NGF<\/jats:italic>\n                    increased as the tumor stage advanced. For ten neuropeptides, their expression levels were lower in cancer. Thirty synapse\u2010related products displayed their respective expression status between cancer and normal tissues.\n                    <jats:italic>SYPL1<\/jats:italic>\n                    ,\n                    <jats:italic>SYBP2\/3<\/jats:italic>\n                    , and\n                    <jats:italic>STX4<\/jats:italic>\n                    had a significant impact on tumor prognosis. Higher levels of\n                    <jats:italic>syntaxin\u20104<\/jats:italic>\n                    ,\n                    <jats:italic>neugrin<\/jats:italic>\n                    , and\n                    <jats:italic>other<\/jats:italic>\n                    axogenesis products were associated with a worse prognosis in cancer. Moreover, immunohistochemistry revealed that NSC\u2010like CA\u2010MSCs were abundant in cancer and exhibited a clear growth\u2010promoting effect on cancer. Briefly, CA\u2010MSCs, which are densely distributed in cancer and have the characteristics of NSCs, express a large number of nerve\u2010related products. These products may have significant effects on tumor progression and prognosis.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72199","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:16:32Z","timestamp":1788160592000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Expression and Prognosis of Neural\u2010Related Products Expressed by Cancer\u2010Derived Mesenchymal Stem Cells With the Characteristics of Neural Stem Cells"],"prefix":"10.1002","volume":"15","author":[{"given":"Liu","family":"Yongjun","sequence":"first","affiliation":[{"name":"Department of Endoscopy Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Zhiwen","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Department Zhejiang 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