{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:19:15Z","timestamp":1787663955928,"version":"build-2736575974"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    There are no reliable screening tests for pancreatic ductal adenocarcinoma (PDAC). We performed this study to address this issue. Using 206 serum samples from 95 healthy subjects and 111 patients with PDAC, we developed the novel ACAm\u2010S index, which consists of age, CA19\u20109, and methylated\n                    <jats:italic>somatostatin<\/jats:italic>\n                    . The ACAm\u2010S index showed a sensitivity of 91.0% (101\/111) for all stages of PDAC and a specificity of 94.7% (90\/95). Notably, its sensitivity was high at 85.4% (35\/41), even for Stage I PDAC. The ACAm\u2010S index may have potential as a blood\u2010based screening tool for early\u2010stage PDAC in the general population.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72202","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T06:34:37Z","timestamp":1787380477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Index Consisting of Age,\n                    <scp>CA19<\/scp>\n                    \u20109, and Methylated\n                    <i>Somatostatin<\/i>\n                    Is Useful for Diagnosing Early Pancreatic Cancer"],"prefix":"10.1002","volume":"15","author":[{"given":"Shoko","family":"Tabara","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8822-0053","authenticated-orcid":false,"given":"Yutaka","family":"Suehiro","sequence":"additional","affiliation":[{"name":"Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Suehiro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ukyo","family":"Shinagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Hamamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Tsuyama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4128-2177","authenticated-orcid":false,"given":"Shuhei","family":"Shinoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3726-5961","authenticated-orcid":false,"given":"Shigeyuki","family":"Suenaga","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3688-4051","authenticated-orcid":false,"given":"Yuki","family":"Kunimune","sequence":"additional","affiliation":[{"name":"Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuei","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Health Screening Ajisu Kyoritsu Hospital  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1362-9348","authenticated-orcid":false,"given":"Chieko","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Ajisu Kyoritsu Hospital  Yamaguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Higaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology St. Hill Hospital  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-4989","authenticated-orcid":false,"given":"Taro","family":"Takami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9793-0399","authenticated-orcid":false,"given":"Takahiro","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine  Ube Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000527342"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2006.10.004"},{"key":"e_1_2_11_4_1","first-page":"93","volume-title":"TNM Classification of Malignant Tumours","author":"Brierley J. D.","year":"2017"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000536211"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2009.04174.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878\u20100261.12684"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2021.05.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201020\u20100235"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2024.0210"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72202","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:25:54Z","timestamp":1787660754000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":9,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/cam4.72202"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72202","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72202"}}