{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:52:46Z","timestamp":1791179566927,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1ZIABC011786\u201003"],"award-info":[{"award-number":["1ZIABC011786\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary brain tumor (PBT) patients commonly experience cognitive dysfunction. This study aims to describe the prevalence and factors associated with perceived cognitive function (PCF) in PBT patients enrolled in a natural history study (NCT02851706: Principal Investigator T. S. Armstrong).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The Neuro\u2010QoL Cognition Function was used to measure PCF with T\u2010scores &lt;\u200940 categorized as cognitively impaired. Clinical and demographic characteristics, patient\u2010reported outcomes (PROs: symptom burden, depression, anxiety), and KPS were collected and characterized using descriptive statistics. Univariate tests on PCF with\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt;\u20090.10 were performed and included in a subsequent multivariate logistic regression with backward selection. Clinical variables and PROs were evaluated separately, then combined for a final multivariate model with\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value &lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 327 patients (median age: 47\u2009years [range: 18\u201385], primarily white [78%] males [55%] with high\u2010grade tumors [73%]). Perceived cognitive impairment occurred in 29% of patients. Patients presenting with cognitive dysfunction at diagnosis, or who had undergone multiple surgeries, were more likely to have poor PCF, as were those currently on corticosteroids and reporting cognitive symptoms and symptom interference. Evaluated together, a multivariate model found that only higher scores on symptom interference and the cognitive symptom factor increased the likelihood of cognitive impairment (symptom interference odds ratio [OR]\u2009=\u20091.25, 95% confidence interval [CI] [1.09, 1.44],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; cognitive symptom factor OR\u2009=\u20091.81, 95% CI [1.50, 2.19],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) with an 84% classification rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Self\u2010reported cognitive symptoms and interference were the strongest patient\u2010reported correlates of PCF and should be interpreted as concurrent associations among related constructs. Further psychometric and longitudinal work is needed to clarify the incremental clinical value of the Neuro\u2010QoL Cognition Function Short Form in PBT care and research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72203","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:13:47Z","timestamp":1791177227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Factors Associated With Perceived Cognitive Dysfunction in Patients With Primary Brain Tumors: The Utility of the Neuro\u2010\n                    <scp>QoL<\/scp>\n                    Cognition Function Scale"],"prefix":"10.1002","volume":"15","author":[{"given":"Morgan","family":"Johnson","sequence":"first","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Reinhart","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian A.","family":"Guedes","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9348-8740","authenticated-orcid":false,"given":"Michelle L.","family":"Wright","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Vera","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"},{"name":"Office of Patient\u2010Centered Outcomes Research National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-1312","authenticated-orcid":false,"given":"Alvina","family":"Acquaye\u2010Mallory","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hope","family":"Miller","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Choi","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"Kunst","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Reyes","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Penas\u2010Prado","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Branch National Cancer Institute, National 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