{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:46Z","timestamp":1791262606556,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["W0014"],"award-info":[{"award-number":["W0014"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neurological immune\u2010related adverse events (N\u2010irAEs) from immune checkpoint inhibitors (ICIs) are rare but potentially fatal. This study aimed to characterize their real\u2010world profile to support early detection and management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed ICI\u2010associated individual case safety reports (ICSRs) in the FDA Adverse Event Reporting System (FAERS) from April 2011 to June 2023. Disproportionality analyses used the reporting odds ratio (ROR) and the Bayesian confidence propagation neural network (BCPNN). Associations between serious N\u2010irAEs and sex or age group (&lt;\u200960 vs. \u2265\u200960\u2009years) were assessed using chi\u2010squared tests. We also evaluated the co\u2010occurrence of myasthenia gravis with myositis and\/or myocarditis and its association with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3486 ICSRs involving N\u2010irAEs were identified, with 550 cases reporting fatal outcomes. A total of 4139\u2009N\u2010irAE signals were detected; among these, 2560 signals corresponded to the top 10 Preferred Terms (PTs) with the highest reporting frequencies. The median time from ICI initiation to the onset of N\u2010irAEs was 82\u2009days (IQR: 29\u2013219\u2009days). Of the 4139\u2009N\u2010irAE signals, 1925 (46.5%) were classified as serious adverse events; no statistically significant differences were observed in their distribution by sex (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20092.492,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.114) or age (\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20092.946,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.086). A total of 461 cases of myasthenia gravis were identified, of which 219 (47.5%) were concomitant with myocarditis and\/or myositis. Among the 137 fatal cases of myasthenia gravis, 70 (51.1%) were concomitant with myocarditis and\/or myositis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study offers a comprehensive characterization of N\u2010irAEs, highlights the fatality risk when myasthenia gravis co\u2010occurs with myocarditis and\/or myositis, and underscores the importance of early recognition, multi\u2010system evaluation, and timely intervention to improve patient safety and optimize the risk\u2013benefit balance of immunotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72206","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:56:59Z","timestamp":1787813819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurological Adverse Events Associated With Immune Checkpoint Inhibitors Identified Through Disproportionality Analysis of the\n                    <scp>FDA<\/scp>\n                    Adverse Event Reporting System"],"prefix":"10.1002","volume":"15","author":[{"given":"Tao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1914-4992","authenticated-orcid":false,"given":"Kexin","family":"Shu","sequence":"additional","affiliation":[{"name":"Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9868-0419","authenticated-orcid":false,"given":"Hongyi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0184-9447","authenticated-orcid":false,"given":"Yonghua","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9333-0525","authenticated-orcid":false,"given":"Fujun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1232-1381","authenticated-orcid":false,"given":"Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The First Affiliated Hospital of Chongqing Medical University  Chongqing 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