{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:19:03Z","timestamp":1787663943699,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NU21\u201003\u201000306"],"award-info":[{"award-number":["NU21\u201003\u201000306"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Programmed death\u2010ligand 1 (PD\u2010L1) has emerged as a potential biomarker for prognosis and treatment response in various solid tumors. However, its clinical relevance in ovarian carcinoma (OC) remains unclear, with published studies reporting inconsistent associations with platinum sensitivity and survival. These discrepancies are likely related to the biological heterogeneity of OC and methodological variability in PD\u2010L1 evaluation. In the absence of a standardized, OC\u2010specific assessment methodology, the Combined Positive Score (CPS) with cutoffs of \u2265\u20091 and \u2265\u200910, applied in other tumor types, represents a pragmatic approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed a real\u2010world cohort of 146 patients with ovarian carcinoma treated with primary platinum\u2010based chemotherapy at University Hospital Brno between 2010 and 2020. PD\u2010L1 expression was assessed using the 22C3 antibody and CPS methodology on archival, treatment\u2010naive tumor samples obtained from primary tumors or metastatic lesions. Associations between PD\u2010L1 status, platinum treatment\u2010free interval (TFIp), and disease\u2010specific survival (DSS) were evaluated, including subgroup analyses by histological subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 144 evaluable cases, 65 patients (45%) demonstrated positive PD\u2010L1 expression (CPS \u2265\u20091), while 35 patients (24%) exhibited strong positive expression (CPS \u2265\u200910). In the high\u2010grade serous carcinoma (HGSC) subgroup, CPS \u2265\u20091 and CPS \u2265\u200910 were detected in 58\/121 (48%) and 30\/121 (25%) cases, respectively. PD\u2010L1 positivity did not differ significantly between HGSC and non\u2010HGSC subtypes or between primary and metastatic lesions. PD\u2010L1 positivity defined as CPS \u2265\u200910 was significantly associated with platinum sensitivity (TFIp \u2265\u20096\u2009months;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035 overall;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028 in HGSC) and longer DSS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029). No associations were observed when PD\u2010L1 positivity was defined using a CPS \u2265\u20091 cutoff.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PD\u2010L1 expression assessed by CPS, particularly at a cutoff of \u2265\u200910, may have prognostic relevance in ovarian cancer and could help identify patients more likely to benefit from platinum\u2010based chemotherapy. Prospective validation is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72216","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T04:50:40Z","timestamp":1787547040000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of\n                    <scp>PD<\/scp>\n                    \u2010\n                    <scp>L1<\/scp>\n                    Expression in Ovarian Cancer: Analysis of a Real\u2010World Cohort Treated With Primary Platinum\u2010Based Chemotherapy"],"prefix":"10.1002","volume":"15","author":[{"given":"Jitka","family":"Hausnerova","sequence":"first","affiliation":[{"name":"Department of Pathology University Hospital Brno and Faculty of Medicine, Masaryk University Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Ovesna","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses, Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Ehrlichova","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hematology and Oncology University Hospital Brno and Faculty of Medicine, Masaryk University Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Felsinger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brno and Faculty of Medicine, Masaryk University Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Nalezinska","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Department of Surgical Oncology Masaryk Memorial Cancer Institute and Medical Faculty of Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kvetoslava","family":"Matulova","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital Brno and Faculty of Medicine, Masaryk University Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubos","family":"Minar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brno and Faculty of Medicine, Masaryk University Brno  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leos","family":"Kren","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital Brno and Faculty of Medicine, Masaryk University Brno  Brno Czech 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