{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:00Z","timestamp":1791262560256,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002643"],"award-info":[{"award-number":["82002643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>ER stress (ERS) influences tumor behavior through the unfolded protein response (UPR), yet its role in glioma is not fully defined. This study investigated the function of the ERS\u2010related regulator QRICH1 in glioma progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Public databases (TCGA and GTEx) were used to evaluate QRICH1 expression, survival, and prognostic significance in glioma. Lentiviral QRICH1 overexpression or knockdown was established in U87 and U251 cells, followed by functional and mechanistic assays. A subcutaneous xenograft model, histological analyses, and immunohistochemistry were performed to validate the biological function of QRICH1 in\u00a0vivo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>QRICH1 was markedly upregulated in glioma and associated with better patient survival. QRICH1 overexpression suppressed glioma proliferation, migration, and invasion while promoting apoptosis, whereas silencing QRICH1 enhanced malignancy. Mechanistically, QRICH1 activated the PERK\u2010ATF4\u2010CHOP pathway, increased caspase\u201012 cleavage, and strengthened ERS\u2010induced apoptosis. In\u00a0vivo, QRICH1 overexpression reduced tumor size and increased apoptotic markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>QRICH1 shifts QRICH1 shifts the UPR toward its pro\u2010apoptotic branch, thereby inhibiting glioma progression, and represents a promising prognostic biomarker and therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72217","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:31:23Z","timestamp":1788413483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>QRICH1<\/scp>\n                    Suppresses Glioma Progression by Inducing\n                    <scp>ER<\/scp>\n                    Stress and Activating the\n                    <scp>PERK<\/scp>\n                    \u2010\n                    <scp>ATF4<\/scp>\n                    \u2010\n                    <scp>CHOP<\/scp>\n                    Pathway"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3052-2261","authenticated-orcid":false,"given":"Yunjiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital  Yancheng Jiangsu Province China"},{"name":"Department of Neurosurgery &amp; Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow University, Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital  Yancheng Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenglou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital  Yancheng Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqi","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital  Yancheng Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated Hospital 6 of Nantong University, Yancheng Third People's Hospital  Yancheng Jiangsu Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Affiliated 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