{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:57:32Z","timestamp":1791262652479,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFE0206600"],"award-info":[{"award-number":["2021YFE0206600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172842"],"award-info":[{"award-number":["82172842"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672386"],"award-info":[{"award-number":["81672386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Currently, there is no clear guidance on the appropriate population or timing for adaptive radiotherapy (ART) in high\u2010grade glioma (HGG) patients. This study aims to provide individualized ART for HGG patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants received standard \u201cradiotherapy combined with temozolomide\u201d and underwent MRI before radiotherapy (FX0), after fraction 10 (FX10), and after fraction 20 (FX20). The primary endpoint was anatomical and dosimetric changes in targets and organs at risk (OARs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 73 eligible patients, significant anatomical changes occurred during chemoradiotherapy, particularly at FX10. ART significantly improved target dose coverage and reduced OAR doses compared with projection plans. Univariable and multivariable logistic regression analysis identified Relative volume change (Vrel)_CTV \u2265\u20097% as an independent risk factor for dosimetric changes, with IDH wild\u2010type and tumor diameters &lt;\u20095\u2009cm as independent risk factors. Median follow\u2010up was 12\u2009months; median progression\u2010free survival (PFS) was 18\u2009months. D_migration_max_CTV \u2265\u20098.5\u2009mm was associated with worse PFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Implementing ART after FX10 is recommended. HGG patients with wild\u2010type IDH and tumor diameters &lt;\u20095\u2009cm should be prioritized for ART. Patients with D_migration_max_CTV \u2265\u20098.5\u2009mm require more intensive treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      The trial was prospectively registered (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , NCT06201351)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72225","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:55:36Z","timestamp":1788238536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study of Adaptive Radiotherapy for High\u2010Grade Glioma Based on Interfraction\n                    <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"15","author":[{"given":"Shuangshuang","family":"He","sequence":"first","affiliation":[{"name":"Division of Head &amp; Neck Tumor Multimodality Treatment, Cancer Center West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Physics &amp; Technology West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5724-6541","authenticated-orcid":false,"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6227-0397","authenticated-orcid":false,"given":"Qing","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3186-6854","authenticated-orcid":false,"given":"Yunhui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Head &amp; Neck Tumor Multimodality Treatment, Cancer Center West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Head &amp; Neck Tumor Multimodality Treatment, Cancer Center West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantai","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Head &amp; Neck Tumor Multimodality Treatment, Cancer Center West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Head &amp; Neck Tumor Multimodality Treatment, Cancer Center West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-718X","authenticated-orcid":false,"given":"Xingchen","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, Cancer Center West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3722-3334","authenticated-orcid":false,"given":"Yanhui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8972-7405","authenticated-orcid":false,"given":"Ping","family":"Ai","sequence":"additional","affiliation":[{"name":"Division of Head &amp; Neck Tumor Multimodality Treatment, Cancer Center West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.1789"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70181-2"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-012-0992-y"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02886-9"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90727-Y"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(91)90007-9"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/10315979"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.091"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.09.001"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.10.002"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.04.001"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S300094"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.09.022"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15051555"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.10819"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21707"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.09.028"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12361"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12359"},{"issue":"2","key":"e_1_2_13_23_1","article-title":"A Promising Result of Locoregional Tumor Control With Biologically Adaptive Radiotherapy in Patients With Locally Advanced Non\u2010Small Cell Lung Cancer","volume":"7","author":"Matsuo Y.","year":"2018","journal-title":"Translational Lung Cancer Research"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.05.018"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2017.04.023"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533034616662165"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00748"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.03.001"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3747\/co.v17i6.574"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdae199"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.10.010"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2013.28.8.1233"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5635-z"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-7-220"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14425"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.10.048"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2015.12.003"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-9-20"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2019.10.019"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2022.05.036"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110145"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.01.024"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.20.4037"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2019.242"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.06.004"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/nop\/npv016"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040937"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12050632"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.06.2214"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad258"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2022.07.448"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.16669"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noad045"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.03.036"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/cns.70905"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1060098"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:44:14Z","timestamp":1791261854000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cam4.72225"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72225","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2025-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72225"}}