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The genomic drivers underlying this molecular subgroup remain incompletely characterized. Whole\u2010exome sequencing was performed on 302 invasive cervical cancers from Guatemala and Venezuela. Structural variation analysis was conducted using SNP\u2010array and whole\u2010genome sequencing data. Findings were replicated in more than 4600 additional cervical cancer samples from TCGA, AACR Project GENIE, MSKCC, and Caris datasets.\n                    <jats:italic>TP53<\/jats:italic>\n                    mutations were more frequent in adenocarcinoma than SCC, particularly in HPV\u2010negative tumors.\n                    <jats:italic>STK11<\/jats:italic>\n                    alterations, including mutations and focal deletions, were significantly enriched in HPV\u2010positive adenocarcinomas compared with SCC and affected 23% of adenocarcinomas overall. Whole\u2010genome analyses identified recurrent focal deletions, inversions, chromosomal rearrangements, and breakage\u2010fusion\u2010bridge events involving chromosome 19p and\n                    <jats:italic>STK11<\/jats:italic>\n                    that were not detected by exome sequencing alone.\n                    <jats:italic>STK11<\/jats:italic>\n                    alterations were associated with younger age at diagnosis, poorer overall survival, and inferior outcomes following immune checkpoint inhibitor (ICI) therapy.\n                    <jats:italic>STK11<\/jats:italic>\n                    alterations significantly co\u2010occurred with\n                    <jats:italic>YAP1<\/jats:italic>\n                    amplification but were largely mutually exclusive with\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    mutation. Cervical adenocarcinomas also demonstrated significantly lower\n                    <jats:italic>CD274<\/jats:italic>\n                    (PD\u2010L1) expression than SCC.\n                    <jats:italic>STK11<\/jats:italic>\n                    alterations define a distinct molecular subgroup of cervical adenocarcinoma characterized by structural disruption of chromosome 19p, younger age at onset, and poorer clinical outcomes. These findings have implications for molecular classification and future targeted therapeutic approaches in cervical cancer.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72228","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:41:00Z","timestamp":1788759660000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>\n                      <i>STK11<\/i>\n                    <\/scp>\n                    Mutations and Deletions Define an Aggressive Molecular Subgroup of Cervical Adenocarcinoma"],"prefix":"10.1002","volume":"15","author":[{"given":"Emma W.","family":"Robinson","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, National Institutes of Health  Rockville Maryland USA"},{"name":"Cancer Genomics Research Laboratory Frederick National Laboratory for Cancer Research  Rockville Maryland 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