{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:51:03Z","timestamp":1791265863500,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2023YFS0473"],"award-info":[{"award-number":["2023YFS0473"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the prognostic value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in patients with locally advanced nasopharyngeal carcinoma (LANPC) receiving concurrent chemoradiotherapy (CCRT), and to clarify its predictive significance for overall survival (OS), progression\u2010free survival (PFS), locoregional failure\u2010free survival (LRFFS), and distant metastasis\u2010free survival (DMFS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Clinical data of 295 patients with LANPC who received CCRT between April 2021 and April 2022 were retrospectively analyzed. Routine blood and biochemical indices were collected within 1\u2009week before CCRT. The HALP score was calculated as follows: HALP\u2009=\u2009[hemoglobin (g\/L)\u2009\u00d7\u2009albumin (g\/L)\u2009\u00d7\u2009lymphocytes (10\n                      <jats:sup>9<\/jats:sup>\n                      \/L)]\/platelets (10\n                      <jats:sup>9<\/jats:sup>\n                      \/L). Patients were divided into high and low HALP groups with the median as the cutoff point. Kaplan\u2013Meier analysis was used to draw survival curves. The log\u2010rank test was used to compare the survival differences between the high and low HALP groups. Univariate and multivariate Cox regression models were applied to identify independent prognostic factors for patients with LANPC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Survival analysis showed that the 3\u2010year OS of the high and low HALP groups were 95.27% and 93.20%, the 3\u2010year PFS were 87.84% and 74.15%, and the 3\u2010year DMFS were 87.84% and 78.91%, respectively. The differences between the groups were statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). While the 3\u2010year LRFFS were 97.30% vs. 96.60%, there were no statistically significant differences between the groups. Multivariate Cox regression analysis confirmed that a low HALP score was an independent risk factor for OS and PFS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The HALP group is an effective predictor of prognosis in patients with LANPC. A low HALP group indicated higher disease progression and death. This measurement can be used for prognostic stratification and individualized treatment decision\u2010making, both simply and economically, and provides a reference for clinical decision\u2010making and individualized treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72234","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:01:05Z","timestamp":1788411665000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Hemoglobin, Albumin, Lymphocyte, and Platelet Score in Locally Advanced Nasopharyngeal Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"given":"JunMei","family":"Song","sequence":"first","affiliation":[{"name":"Oncology Department Beijing Anzhen Nanchong Hospital, Capital Medical University (Nanchong Central Hospital)  Nanchong Sichuan China"},{"name":"The Second Clinical Medical College of North Sichuan Medical College  Nanchong Sichuan China"},{"name":"Department of Radiation Oncology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"},{"name":"Oncology Department The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine (Xianhu District)  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"},{"name":"Second Division of Department of Radiation Oncology Guangxi Academy of Medical, Sciences &amp; The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning Guangxi 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