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We report genomic and transcriptomic analysis results of 163 NPC cases, demonstrating that somatostatin receptor 2 (\n                    <jats:italic>SSTR2<\/jats:italic>\n                    ) gene expression in EBV\u2010positive and in EBV\u2010negative NPC correlated with genomic alterations and an inflamed microenvironment. Median\n                    <jats:italic>SSTR2<\/jats:italic>\n                    expression was 6.52 transcripts per million (TPM), ranging from 0.59 TPM (Quartile 1 [Q1], 18.2% EBV\u2010positive) to 35.79 TPM (Q4, 82.9% EBV\u2010positive).\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    (20.51%) and\n                    <jats:italic>CYLD<\/jats:italic>\n                    (10.53%)\/\n                    <jats:italic>NFKBIA<\/jats:italic>\n                    (12.82%) mutations were enriched in\n                    <jats:italic>SSTR2<\/jats:italic>\n                    \u2010Q1 versus \u2010Q4. Tumor mutation burden was negatively correlated (\n                    <jats:italic>R<\/jats:italic>\n                    \u2009=\u2009\u22120.27,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) with\n                    <jats:italic>SSTR2<\/jats:italic>\n                    , while PD\u2010L1 tumor proportion score (2% vs. 92.5% [\n                    <jats:italic>SSTR2<\/jats:italic>\n                    :Q1 vs. Q4],\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and T\u2010cell inflamed score correlated with\n                    <jats:italic>SSTR2<\/jats:italic>\n                    expression (\n                    <jats:italic>R<\/jats:italic>\n                    \u2009=\u20090.53,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). B\u2010cells, M1 macrophages, CD8+ T\u2010cells, Treg cells, and dendritic cells were enriched in\n                    <jats:italic>SSTR2<\/jats:italic>\n                    \u2010Q4, while neutrophils were prominent in\n                    <jats:italic>SSTR2<\/jats:italic>\n                    \u2010Q1. These results demonstrate a significant positive correlation between\n                    <jats:italic>SSTR2<\/jats:italic>\n                    expression and an inflamed tumor microenvironment in NPC. This suggests that\n                    <jats:italic>SSTR2<\/jats:italic>\n                    expression in NPC may be a clinically useful biomarker, correlating with the tumor microenvironment (including, potentially, sensitivity to immunotherapy) and its genetic profile.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72239","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T06:56:41Z","timestamp":1788159401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Molecular and Immunological Landscape in Nasopharyngeal Carcinoma (\n                    <scp>NPC<\/scp>\n                    ) Differs by Somatostatin Receptor 2 (\n                    <i>SSTR2<\/i>\n                    ) Expression"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-1079","authenticated-orcid":false,"given":"Dara","family":"Bracken\u2010Clarke","sequence":"first","affiliation":[{"name":"Center for Immuno\u2010Oncology, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Xue","sequence":"additional","affiliation":[{"name":"Center for Immuno\u2010Oncology, Center for Cancer Research, National Cancer Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harris","family":"Krause","sequence":"additional","affiliation":[{"name":"CARIS Life Sciences  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tolulope","family":"Adeyelu","sequence":"additional","affiliation":[{"name":"CARIS Life Sciences  Phoenix 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