{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:39:04Z","timestamp":1792809544852,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>CD40<\/jats:italic>\n                    gene, a key immune regulatory molecule, has been implicated in tumorigenesis, and its functional polymorphism rs1883832 located in the Kozak sequence, may modulate cancer susceptibility by influencing\n                    <jats:italic>CD40<\/jats:italic>\n                    expression. To clarify inconsistent epidemiological findings, a comprehensive meta\u2010analysis was conducted to evaluate the association between the\n                    <jats:italic>CD40<\/jats:italic>\n                    rs1883832 polymorphism and overall cancer risk. Eligible case\u2013control studies were systematically identified from PubMed, Web of Science and Cochrane Library up to August 15, 2025, and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated under five genetic models. Eight studies encompassing 3858 cancer cases and 4699 controls met the inclusion criteria. The results revealed a significant association between the rs1883832 T allele and elevated cancer risk in 4 multiple models, including the allele (T vs. C: OR\u2009=\u20091.26, 95% CI: 1.09\u20131.47,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), homozygous (TT vs. CC: OR\u2009=\u20091.58, 95% CI: 1.16\u20132.16,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), recessive (TT vs. TC\u2009+\u2009CC: OR\u2009=\u20091.43, 95% CI: 1.18\u20131.82,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), and dominant (TT\u2009+\u2009TC vs. CC: OR\u2009=\u20091.29, 95% CI: 1.03\u20131.62,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) models. Subgroup analyses revealed suggestive patterns of associations in lung cancer and Asian populations. Sensitivity analyses confirmed the robustness of these findings, and no substantial publication bias was detected. In conclusion, this meta\u2010analysis provides compelling evidence that the\n                    <jats:italic>CD40<\/jats:italic>\n                    rs1883832 T allele may confer increased susceptibility to cancer, thereby underscoring the potential influence of immune gene polymorphisms in carcinogenesis and their relevance for genetic risk assessment in oncology.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO number: CRD420251130223\n                  <\/jats:p>","DOI":"10.1002\/cam4.72243","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:05:48Z","timestamp":1791867948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Association Between\n                    <scp>CD40<\/scp>\n                    rs1883832 Polymorphism and Cancer Susceptibility: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-5572","authenticated-orcid":false,"given":"Bingxiang","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[{"name":"Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhao","family":"Fan","sequence":"additional","affiliation":[{"name":"Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiju","family":"Ge","sequence":"additional","affiliation":[{"name":"Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35278"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"issue":"12","key":"e_1_2_12_5_1","article-title":"Exploring the Role of Chemicals and Environmental Factors for Cancer Proliferation","volume":"11","author":"Ullah A.","year":"2024","journal-title":"Open Access Library Journal"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.743"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01907"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09025-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1102-991"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00782.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.004313"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2019.151899"},{"issue":"18","key":"e_1_2_12_13_1","first-page":"10","article-title":"Association Between the CD40 rs1883832 Polymorphism and Graves' Disease Risk: A Meta\u2010Analysis","volume":"23","author":"Wang X. X.","year":"2019","journal-title":"EXCLI Journal"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097289"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.721577"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CEJ.0000000000000671"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13277"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023762"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25420"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5937\/jomb0-49044"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2024-109879"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"issue":"4","key":"e_1_2_12_23_1","first-page":"719","article-title":"Statistical Aspects of the Analysis of Data From Retrospective Studies of Disease","volume":"22","author":"Mantel N.","year":"1959","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0312576"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.71027"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-112144"},{"issue":"11","key":"e_1_2_12_27_1","first-page":"15163","article-title":"CD40 \u20101C>T Polymorphism and the Risk of Lung Cancer in a Chinese Population","volume":"8","author":"Zhou G.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2010.1129"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27794"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198443"},{"issue":"35","key":"e_1_2_12_31_1","first-page":"2745","article-title":"CD40\/TNF Receptor Associated Factor 1 Expression and NF\u2010\u03baB\u2010Dependent Proinflammatory Gene Expression in Rheumatoid Arthritis","volume":"99","author":"Cheng T.","year":"2019","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122688"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23832-3"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-062518-045435"},{"issue":"3","key":"e_1_2_12_35_1","first-page":"69","article-title":"CD40\/CD40 Ligand Interactions in Immune Responses and Pulmonary Immunity","volume":"73","author":"Kawabe T.","year":"2011","journal-title":"Nagoya Journal of Medical Science"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv279"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.10.009"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:07:56Z","timestamp":1792807676000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cam4.72243"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72243","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2025-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72243"}}