{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:57:31Z","timestamp":1791262651230,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated how inflammatory cell death\u2010associated regulators influence the prognosis of lung adenocarcinoma (LUAD) and elucidated their underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>LUAD RNA\u2010seq data from UCSC\u2010Xena (training) and GSE72094 (validation) were analyzed. Inflammatory cell death regulators were identified, and LUAD subtypes were classified based on their expression. Subtypes were compared with respect to prognosis, clinical features, immune microenvironment, HLA genes, and immune checkpoints. Prognosis\u2010related regulators and independent factors were identified, and a RiskScore model was built. Genomic alterations, drug sensitivity, immunotherapy response, and metabolic differences were analyzed across risk\u2010stratified cohorts. Knockdown of TFDP1 in A549 cells was performed in\u00a0vitro, and its effects on cell function were evaluated via RT\u2010qPCR, Western blot, CCK\u20108, Transwell, and flow cytometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The research revealed 15 upregulated and 9 downregulated genes associated with inflammatory cell death, which were employed to stratify LUAD cases into two subtypes (Cluster 2 exhibited longer overall survival and higher immune\/stromal scores). The seven\u2010gene prognostic model (comprising BAK1, BMF, CYCS, FADD, IL1A, TFDP1, and YWHAG) demonstrated robust predictive power for LUAD patient survival risk. Notably, the high\u2010risk cohort exhibited higher TIDE scores and lower IPS scores than the low\u2010risk group. IL1A was positively correlated with 11 immune cell types and negatively correlated with 4. Drugs such as docetaxel and parthenolide may target this model. The study identified significant differences in 14 metabolic pathway enrichments between risk groups, particularly in fatty acid and fructose metabolism. Experimental validation confirmed TFDP1 upregulation in LUAD, and its knockdown suppressed A549 cell proliferation, migration, and invasion while inducing apoptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A seven\u2010gene inflammatory cell death\u2010based signature for LUAD was developed, highlighting its role in immune regulation and its potential for immunotherapy. Experimental validation identified TFDP1 as a key regulator of inflammatory cell death processes in LUAD progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72255","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:02:34Z","timestamp":1789794154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Inflammatory Cell Death\u2010Related Prognostic Signature and Its Regulatory Mechanism in Lung Adenocarcinoma"],"prefix":"10.1002","volume":"15","author":[{"given":"Yalun","family":"Yang","sequence":"first","affiliation":[{"name":"Jingzhou Central Hospital  Jingzhou China"},{"name":"Jingzhou Hospital Affiliated to Yangtze University  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Liu","sequence":"additional","affiliation":[{"name":"Jingzhou Central Hospital  Jingzhou China"},{"name":"Jingzhou Hospital Affiliated to Yangtze University  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0673-5045","authenticated-orcid":false,"given":"Shengwei","family":"Ma","sequence":"additional","affiliation":[{"name":"Jingzhou Central Hospital  Jingzhou China"},{"name":"Jingzhou Hospital Affiliated to Yangtze University  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/cm9.0000000000002108"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27813"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2020.07.012"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/ott.S342613"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcac033"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2022.100069"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab561"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki022"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.1007108"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/106652703322756131"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg034"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq170"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102105\u201014\u20107"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20107493\u20101_12"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2020.08.004"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010016\u20101070\u20105"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3612"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr260"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10533"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1753\u20106561\u20106\u2010s2\u2010s10"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.239244.118"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021254\u20109"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107468"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100136\u20101"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.033"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.019"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000028500"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.Mct\u201007\u20102299"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010014\u20101688\u20104"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.12.083"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.11.136"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.191"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15027646"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.05.005"},{"issue":"2","key":"e_1_2_13_37_1","first-page":"1","article-title":"Docetaxel (Taxotere) in the Treatment of Cancer","volume":"27","author":"Burris H. 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