{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:11Z","timestamp":1791262571880,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170221"],"award-info":[{"award-number":["82170221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Central nervous system (CNS) involvement in B\u2010cell acute lymphoblastic leukemia (B\u2010ALL) is associated with relapse, treatment refractoriness, and poor prognosis. Although chimeric antigen receptor (CAR) T cell therapy has demonstrated remarkable efficacy in relapsed\/refractory (R\/R) B\u2010ALL, its efficacy and safety in CNS leukemia (CNSL) remain unclear. We retrospectively analyzed 113 R\/R B\u2010ALL patients who received CAR\u2010T cell therapy, stratifying them into CNS\u2010positive (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200922) and CNS\u2010negative (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200991) groups based on the presence of CNSL prior to infusion. At Day 28 after CAR\u2010T infusion, the overall complete remission (CR) rate was 81.8%, with no significant difference between groups. The incidence of cytokine release syndrome (CRS) and neurotoxicity was comparable. The 3\u2010year cumulative incidence of relapse (CIR), event\u2010free survival (EFS), and overall survival (OS) were similar between groups. However, CNSL patients exhibit a higher cumulative relapse rate following CAR\u2010T\u2010induced remission, with an increased risk of CNS relapse compared to patients without CNS involvement. Multivariate analysis identified allo\u2010HSCT as consolidation post\u2010CAR\u2010T as an independent protective factor for improved EFS and OS in CNSL patients. In conclusion, CAR\u2010T therapy offers similar efficacy and safety in R\/R B\u2010ALL patients regardless of CNS involvement. Furthermore, CAR\u2010T cell therapy was not sufficient to maintain sustained remission, and consolidative allo\u2010HSCT may improve long\u2010term survival in this high\u2010risk group.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72262","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:59:38Z","timestamp":1788757178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of CAR\u2010T Cell Therapy in Relapsed\/Refractory B\u2010Cell Acute Lymphoblastic Leukemia With Central Nervous System Involvement"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3677-2164","authenticated-orcid":false,"given":"Yanghong","family":"Yu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of University of Science and Technology of China  Hefei City Anhui Province 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