{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:04Z","timestamp":1791262564076,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y\u2010HR2020MS\u20100948"],"award-info":[{"award-number":["Y\u2010HR2020MS\u20100948"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473192"],"award-info":[{"award-number":["82473192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172741"],"award-info":[{"award-number":["82172741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>TFE3\u2010rearranged renal cell carcinoma (TFE3\u2010rRCC) is uncommon and encompasses biologically diverse tumors, while evidence to guide systemic treatment remains sparse. We examined clinical outcomes, treatment patterns, and molecular features in a multicenter real\u2010world cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed 151 patients with TFE3\u2010rRCC treated at eight centers in China. Treatment analyses included the 59 patients who had metastatic or relapsed disease and sufficiently detailed treatment records. Response was assessed by RECIST version 1.1. Kaplan\u2013Meier methods were used for time\u2010to\u2010event outcomes, and potential confounding was explored with Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median first\u2010line progression\u2010free survival (PFS) was 6.1\u2009months among the 59 treated patients. PFS was longer with first\u2010line ICI\/TKI therapy than with TKI monotherapy (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). In an exploratory multivariable model, distant lymph\u2010node metastasis was associated with shorter overall survival (HR, 5.22; 95% CI, 1.17\u201323.40;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.031). In a small subgroup comparison, NONO\u2010TFE3 tumors had a relatively immune\u2010depleted transcriptomic profile and lower disease control with ICI\/TKI therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>TFE3<\/jats:italic>\n                      \u2010rRCC is a heterogeneous disease with poor survival and a variable therapeutic response. ICI\/TKI combinations had modest activity; newer approaches are needed.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72268","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:29:35Z","timestamp":1789147775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes, Treatment Patterns, and Molecular Heterogeneity of\n                    <scp>TFE3<\/scp>\n                    \u2010Rearranged Renal Cell Carcinoma: A Multicenter Real\u2010World Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6763-8381","authenticated-orcid":false,"given":"Shuxuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Urology, Fudan University Shanghai Cancer Center Fudan University  Shanghai People's Republic of China"},{"name":"Department of Oncology, Shanghai Medical College Fudan 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9532-5654","authenticated-orcid":false,"given":"Qiuli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Urology, Daping Hospital Army Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-209X","authenticated-orcid":false,"given":"Xin","family":"Gou","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Chongqing Medical University  Chongqing People's Republic of 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