{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:51:22Z","timestamp":1791265882079,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Effective treatment options remain limited for patients with recurrent or metastatic head and neck squamous cell carcinoma (R\/M HNSCC), including patients who have progressed after platinum\u2010based chemotherapy and systemic\u2010therapy\u2010na\u00efve patients. This Phase Ib trial evaluates the efficacy and safety of finotonlimab, a PD\u20101 antibody, combined with SCT200, an EGFR antibody.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, multicenter, open\u2010label study enrolled patients into two cohorts: Cohort A (previously treated with platinum\u2010based chemotherapy and immune checkpoint inhibitors) and Cohort B (systemic therapy\u2010na\u00efve). Patients received finotonlimab (200\u2009mg every 3\u2009weeks) and SCT200 (6\u2009mg\/kg weekly for 12\u2009weeks, then 8\u2009mg\/kg every 2\u2009weeks). The primary endpoint was objective response rate (ORR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 41 patients, Cohort A (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911) showed an ORR of 27.3%, median progression\u2010free survival (PFS) of 5.8\u2009months, and median overall survival (OS) of 10.6\u2009months. Cohort B (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200930) had an ORR of 56.7%, median PFS of 9.6\u2009months, and an estimated median OS of 13.6\u2009months. Common treatment\u2010related adverse events included hypomagnesemia (63.4%), rash (41.5%), and acneiform dermatitis (36.6%), which were manageable.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The combination of finotonlimab and SCT200 demonstrates promising efficacy, particularly in systemic therapy\u2010na\u00efve patients, warranting further investigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      identifier: NCT05552807;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/chinadrugtrials.org.cn\">Chinadrugtrials.org.cn<\/jats:ext-link>\n                      identifier: CTR20220917\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72272","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:23:20Z","timestamp":1788841400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase Ib Trial of Finotonlimab Combined With\n                    <scp>SCT200<\/scp>\n                    in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"15","author":[{"given":"Jinguan","family":"Lin","sequence":"first","affiliation":[{"name":"The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University\/Hunan Cancer Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Qu","sequence":"additional","affiliation":[{"name":"Guangxi Medical University Cancer Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuansong","family":"Bai","sequence":"additional","affiliation":[{"name":"The Third Bethune Hospital of Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[{"name":"Chongqing University Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjing","family":"Huang","sequence":"additional","affiliation":[{"name":"Hainan General Hospital  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9369-3640","authenticated-orcid":false,"given":"Meiyu","family":"Fang","sequence":"additional","affiliation":[{"name":"Zhejiang Cancer Hospital  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianling","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Huang","sequence":"additional","affiliation":[{"name":"Sun Yat\u2010sen Memorial Hospital Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianyong","family":"Chen","sequence":"additional","affiliation":[{"name":"West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning Cancer Hospital &amp; 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