{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:36Z","timestamp":1791262596095,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060041"],"award-info":[{"award-number":["82060041"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary bone diffuse large B\u2010cell lymphoma (PB\u2010DLBCL) is a rare extranodal lymphoma with heterogeneous clinical features and survival outcomes. Although most patients respond favorably to modern immunochemotherapy, reliable baseline prognostic indicators remain insufficiently defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 424 patients with histologically confirmed PB\u2010DLBCL. Clinical characteristics, treatment patterns and survival outcomes were evaluated. Overall survival (OS) and progression\u2010free survival (PFS) were estimated using the Kaplan\u2013Meier method. Prognostic factors were assessed by univariate and multivariate Cox regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      With a median follow\u2010up of 36\u2009months, the 3\u2009year OS and PFS rates were 81.3% and 63.3%, respectively. In multivariate analysis, high\u2010risk International Prognostic Index (IPI; score 3\u20135) was independently associated with inferior OS (HR 2.06, 95% CI 1.24\u20133.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). For PFS, hypoalbuminemia (&lt;\u200940\u2009g\/L) emerged as an independent predictor (HR 1.44, 95% CI 1.03\u20132.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). Although failure to achieve complete remission and high Deauville score were associated with worse outcomes in univariate analyses, these post\u2010treatment variables were not included in multivariable models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PB\u2010DLBCL often presents with advanced disease but demonstrates generally favorable survival in the rituximab era. Baseline IPI remains a robust predictor of OS, while hypoalbuminemia independently predicts disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72284","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:40:22Z","timestamp":1789620022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Prognostic Factors of Primary Bone Diffuse Large B\u2010Cell Lymphoma: A Retrospective Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5219-6630","authenticated-orcid":false,"given":"Zhenbo","family":"Hou","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"},{"name":"Research Center for Lymphoma Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2627-0332","authenticated-orcid":false,"given":"Kebing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"},{"name":"Research Center for Lymphoma Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jiajin Hospital  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Imaging Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junning","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"},{"name":"Research Center for Lymphoma Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qunling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"},{"name":"Research Center for Lymphoma Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1320-7364","authenticated-orcid":false,"given":"Yizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College Fudan University  Shanghai China"},{"name":"Research Center for Lymphoma Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24828"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.02.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288\u2010020\u201001327\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases11010042"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2401582"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010023\u201005772\u2010w"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S350655"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010024\u201006012\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl329"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.301095088"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999\u2010013\u20102991\u2010x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12841"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.063156"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28834"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.0967"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102407\u201014\u2010900"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181b314ce"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1309\/CMPGPYTMFRM6RVQR"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349\u20107006.2011.02139.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102141.2012.09247.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013\u20100249"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21930"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201099\u2010116845"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100210"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357909809032885"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360\u20103016(97)00106\u20105"},{"issue":"3","key":"e_1_2_11_28_1","first-page":"280","article-title":"Primary Bone Lymphoma: Experience With 52 Patients","volume":"88","author":"Zinzani P. 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