{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:57:37Z","timestamp":1791262657146,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>While psychological distress is a well\u2010documented concern among cancer patients, the prevalence and severity of depression and anxiety in breast cancer patients in Saudi Arabia remain insufficiently explored. This study aimed to evaluate depression, anxiety, and quality of life (QoL) among patients with breast cancer undergoing adjuvant pharmacotherapy in Saudi Arabia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional observational study was conducted among patients with breast cancer receiving adjuvant therapy. Data were collected using the Patient Health Questionnaire\u20109 (PHQ\u20109) for depression, the Generalized Anxiety Disorder\u20107 (GAD\u20107) for anxiety, and the Quality\u2010of\u2010Life Questionnaire\u2010C30 (QLQ\u2010C30) for QoL assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 246 patients, the most prevalent cancer subtype was hormone receptor\u2013positive (65.0%), followed by human epidermal growth factor receptor 2 (HER2)\u2010positive (13.4%), triple\u2010negative (11.0%), and HER2\/hormone receptor\u2010positive (10.6%). Trastuzumab (20.3%) and pembrolizumab (11.0%) were the most commonly administered biological therapies, while letrozole (45.5%) and tamoxifen (22.8%) were the most used hormonal agents. Notably, 48.4% of patients received chemotherapy. The mean\u2009\u00b1\u2009standard deviation (SD) of PHQ\u20109 score was 12.87\u2009\u00b1\u20097.63, and the mean\u2009\u00b1\u2009SD of GAD\u20107 score was 9.55\u2009\u00b1\u20095.53, with clinical significant depression and anxiety of 54.1% and 49.6%, respectively. The mean\u2009\u00b1\u2009SD of the QLQ\u2010C30 score was 58.84\u2009\u00b1\u200924.98. Multivariate analysis revealed that chemotherapy and the number of cycles were significantly associated with higher levels of depression and anxiety. Quality of life was negatively impacted by chemotherapy, endocrine therapy, and the number of treatment cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Depression, anxiety, and reduced QoL are prevalent among breast cancer patients undergoing treatment in Saudi Arabia. Chemotherapy and endocrine therapy contribute significantly to psychological distress, and diminished QoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72288","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:46:24Z","timestamp":1789955184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Determinants of Depression, Anxiety, and Quality of Life in Patients With Breast Cancer in Saudi Arabia: A Focus on Adjuvant Pharmacotherapy"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3237-1792","authenticated-orcid":false,"given":"Mahmoud S.","family":"Abdallah","sequence":"first","affiliation":[{"name":"Department of PharmD, Faculty of Pharmacy Jadara University  Irbid 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