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Melanoma\u2010associated antigen\u2010A (\n                    <jats:italic>MAGEA<\/jats:italic>\n                    ) genes encode cancer testis antigens frequently expressed in tumor tissue and in limited amounts in normal tissues, making them a promising target for cancer immunotherapy. While therapies targeting MAGEA family members have demonstrated promise across various cancers, clinical trials have been limited by substantial toxicities, underscoring the need to precisely identify patient subgroups most likely to benefit from MAGEA\u2010targeted treatments. We performed gene expression analysis of\n                    <jats:italic>MAGEA3, 6<\/jats:italic>\n                    and\n                    <jats:italic>12<\/jats:italic>\n                    in an Australian\u2010based multicenter cohort of 100 GC patients, including 49 intestinal\u2010type GC cases accrued between 1999 and 2009, and compared expression profiles with those of the Cancer Genome Atlas (TCGA) cohort. Expression patterns were determined in histological and TCGA molecular subtypes of GC. Progression\u2010free survival was examined using the log\u2010rank test and Cox proportional hazards modeling.\n                    <jats:italic>MAGEA3, 6<\/jats:italic>\n                    , and\n                    <jats:italic>12<\/jats:italic>\n                    were mainly expressed in intestinal\u2010type GC and were not associated with other clinicopathological variables. Multivariate analyses revealed that elevated expression of these MAGEA members was prognostic of poorer survival in intestinal\u2010type GC patients. In the TCGA cohort, higher\n                    <jats:italic>MAGEA3, 6<\/jats:italic>\n                    , and\n                    <jats:italic>12<\/jats:italic>\n                    expression was observed in intestinal\u2010type GC and the chromosomal instability (CIN) subtype, and associations of poorer progression\u2010free survival with high expression were found. Our findings highlight the differences in GC subtype biology and suggest a potential role for\n                    <jats:italic>MAGEA3, 6<\/jats:italic>\n                    , and\n                    <jats:italic>12<\/jats:italic>\n                    as biomarkers and targets for intestinal\u2010type GC immunotherapy; however, the relatively small intestinal\u2010type GC sample size warrants validation in larger cohorts.\n                  <\/jats:p>","DOI":"10.1002\/cam4.72298","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:55:43Z","timestamp":1789707343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MAGEA<\/scp>\n                    Family Gene Expression Influences Survival in Intestinal\u2010Type Gastric Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3818-8259","authenticated-orcid":false,"given":"Silke","family":"Neumann","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Faculty of Medicine\u2013Dunedin University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Leong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2261-3495","authenticated-orcid":false,"given":"Rita A.","family":"Busuttil","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Translational Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8109-6897","authenticated-orcid":false,"given":"Alex","family":"Boussioutas","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology School of Translational Medicine, Monash University  Melbourne Victoria Australia"},{"name":"Department of Gastroenterology The Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-3423","authenticated-orcid":false,"given":"Sharon T.","family":"Pattison","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Faculty of Medicine\u2013Dunedin University of Otago  Dunedin New Zealand"},{"name":"Health New Zealand \u2010 Te Whatu Ora Capital, Coast and Hutt Valley  Newtown, Wellington New Zealand"},{"name":"Department of Cancer Sciences Faculty of Medical and Health Sciences, University of Auckland  Grafton, Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13480"},{"issue":"1331","key":"e_1_2_14_4_1","first-page":"39","article-title":"Gastric Cancer Location and Histological Subtype in Pacific People and Maori Defies International Trends","volume":"124","author":"Biggar M.","year":"2011","journal-title":"New Zealand Medical Journal"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ans.12915"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183891"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1758835920930359"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.04.042"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.05.010"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i19.5679"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3850"},{"issue":"10","key":"e_1_2_14_12_1","first-page":"2569","article-title":"Distinctive Patterns of Gene Expression in Premalignant Gastric Mucosa and Gastric Cancer","volume":"63","author":"Boussioutas A.","year":"2003","journal-title":"Cancer Research"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02\u201012\u20100833"},{"issue":"12","key":"e_1_2_14_14_1","first-page":"3309","article-title":"A Combined Comparative Genomic Hybridization and Expression Microarray Analysis of Gastric Cancer Reveals Novel Molecular Subtypes","volume":"63","author":"Tay S. 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