{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:40:20Z","timestamp":1792809620318,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["PRE2016.LCC\/NP"],"award-info":[{"award-number":["PRE2016.LCC\/NP"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Active surveillance is recommended as the first\u2010line management for desmoid\u2010type fibromatosis (\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      ); however, data on\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      of the head and neck (H&amp;N) and shoulder regions are limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We examined patients with\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      located in the H&amp;N and shoulder regions, comparing baseline characteristics and event\u2010free survival (\n                      <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>\n                      ). A subgroup analysis was performed among patients initially managed with active surveillance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      H&amp;N accounted for 4% of all\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      cases, and shoulder accounted for 5%. Pain (62% vs. 53% and 33%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) and functional impairment (29% vs. 0% and 6%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002) were significantly more frequent in shoulder\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      compared with H&amp;N\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      at other sites. Regardless of initial management, the 3\u2010year\n                      <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>\n                      rates for H&amp;N and shoulder were similar to those for other locations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.74). Among patients initially managed with active surveillance, the 3\u2010year\n                      <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>\n                      rates for H&amp;N and shoulder were similar to that for\n                      <jats:styled-content style=\"fixed-case\">DF<\/jats:styled-content>\n                      at other locations (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.63).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pain and functional impairment differed significantly by location; however, the outcomes of both H&amp;N and shoulder DF did not differ significantly from those of DF at other locations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This investigation was registered under the clinical trial registration number NCT02867033<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72302","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:10:31Z","timestamp":1792609831000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Head &amp; Neck and Shoulder Desmoid\u2010Type Fibromatosis: Presentation and Natural History of These Ultra\u2010Rare Locations"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5243-1548","authenticated-orcid":false,"given":"Nicolas","family":"Penel","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Centre Oscar Lambret  Lille France"},{"name":"CHU Lille, ULR 2694\u2014Metrics: Evaluation des Technologies de Sant\u00e9 et des Pratiques M\u00e9dicales Univ. Lille  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-9732","authenticated-orcid":false,"given":"Sylvie","family":"Bonvalot","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Institut Curie  Paris France"},{"name":"Universit\u00e9 Paris Sciences et Lettres  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3983-5713","authenticated-orcid":false,"given":"Julien","family":"Elices\u2010Diez","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Oscar Lambret  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Italiano","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institut Bergoni\u00e9  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Verret","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Gustave Roussy  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Emmanuel","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Strasbourg University Hospital  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Dubray\u2010Longeras","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Centre Jean Perrin  Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Guillemet","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Centre Henri Becquerel  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2057-3557","authenticated-orcid":false,"given":"Florence","family":"Duffaud","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Public Assistance\u2014Hospitals of Marseille, La Timone Hospital  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0157-0959","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Bertucci","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Institut Paoli\u2010Calmettes Aix\u2010Marseille Univ.  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9783-5925","authenticated-orcid":false,"given":"Julien","family":"Thery","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Oscar Lambret  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0481-7049","authenticated-orcid":false,"given":"Marie","family":"Vanseymortier","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Oscar Lambret  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Bompas","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Centre Ren\u00e9 Gauduchau  Saint Herblain France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-6261","authenticated-orcid":false,"given":"Nelly","family":"Firmin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institut de Canc\u00e9rologie de Montpellier  Montpellier France"},{"name":"INSERM U1194, IRCM Univ. Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-0205","authenticated-orcid":false,"given":"Sixtine","family":"De Percin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, AP\u2010HP Cochin Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Wallet","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Oscar Lambret  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Piperno\u2010Neumann","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institut Curie  Paris France"},{"name":"INSERM U830 Institut Curie Research Center  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibaud","family":"Valentin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institut Claudius Regaud and Institut Universitaire de Cancerologie, Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Yves","family":"Blay","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Centre L\u00e9on B\u00e9rard Universit\u00e9 Claude Bernard  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-4592","authenticated-orcid":false,"given":"Marie\u2010C\u00e9cile","family":"Le Deley","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centre Oscar Lambret  Lille 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Effectiveness of \u2018West China Classification\u2019 Guided Surgical Treatment of Desmoid\u2010Type Fibromatosis in Shoulder Girdle","volume":"34","author":"Zhou S.","year":"2020","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za 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