{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:58:44Z","timestamp":1790398724969,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatic cancer is associated with a high risk of venous thromboembolism (VTE), with approximately one in five patients developing VTE. Randomized controlled trials have demonstrated that primary thromboprophylaxis is effective and safe in ambulatory patients with pancreatic cancer treated with chemotherapy. Despite international guideline recommendations, thromboprophylaxis appears underused in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess clinical practice regarding VTE prevention in ambulatory patients with pancreatic cancer among medical oncologists in the Netherlands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A nationwide online survey was conducted between March and June 2025 among Dutch medical oncologists involved in pancreatic cancer care. The questionnaire assessed VTE risk perception, use of risk assessment tools, use of thromboprophylaxis, and patient education regarding thrombosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010eight medical oncologists completed the survey. Most respondents (79%) classified the VTE risk in patients with pancreatic cancer as high or very high, yet 63% never prescribed thromboprophylaxis to ambulatory patients receiving chemotherapy. Lack of a national guideline recommendation was the most frequently reported reason for not prescribing thromboprophylaxis (74%). Only 11% of medical oncologists reported using the Khorana score, and only 3% always discussed VTE risk with patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although medical oncologists recognize the high risk of VTE in patients with pancreatic cancer, thromboprophylaxis remains substantially underused in clinical practice in the Netherlands. Limited awareness of risk assessment tools and national guidance were prominent findings that may inform future implementation efforts. These findings provide a benchmark for assessing the impact of the recently updated Dutch guideline on thromboprophylaxis in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72306","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:11:21Z","timestamp":1790395881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevention of Venous Thromboembolism in Patients With Pancreatic Cancer: A Nationwide Survey"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5157-0191","authenticated-orcid":false,"given":"Ruth A. L.","family":"Willems","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Medical Oncology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Department of Functional Coagulation Synapse Research Institute  Maastricht the Netherlands"},{"name":"Thrombosis Expert Center Maastricht Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-1458","authenticated-orcid":false,"given":"Merlijn U. J. E.","family":"Graus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Medical Oncology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"GROW\u2013Research Institute for Oncology &amp; Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-3713","authenticated-orcid":false,"given":"Eline H. E.","family":"van Gansewinkel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Medical Oncology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Department of Functional Coagulation Synapse Research Institute  Maastricht the Netherlands"},{"name":"Thrombosis Expert Center Maastricht Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"GROW\u2013Research Institute for Oncology &amp; Reproduction Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0192-5354","authenticated-orcid":false,"given":"Aniek E.","family":"van Diepen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Medical Oncology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"GROW\u2013Research Institute for Oncology &amp; Reproduction Maastricht University  Maastricht the Netherlands"},{"name":"Department of Medical Oncology Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8712-9825","authenticated-orcid":false,"given":"Geert A.","family":"Cirkel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regional Academic Cancer Center Utrecht, Antonius University Medical Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1274-5643","authenticated-orcid":false,"given":"Hanneke W. M.","family":"van Laarhoven","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam Cancer Treatment and Quality of Life  Amsterdam the Netherlands"},{"name":"Department of Medical Oncology Amsterdam University Medical Center, Location University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam L.","family":"Wumkes","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Jeroen Bosch Hospital  \u2018s\u2010Hertogenbosch the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolein Y. V.","family":"Homs","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Erasmus MC Cancer Institute  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna W.","family":"Wilmink","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam Cancer Treatment and Quality of Life  Amsterdam the Netherlands"},{"name":"Department of Medical Oncology Amsterdam University Medical Center, Location University of Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-0754","authenticated-orcid":false,"given":"F. A.","family":"Klok","sequence":"additional","affiliation":[{"name":"Department of Medicine\u2010Thrombosis and Hemostasis Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5256-6346","authenticated-orcid":false,"given":"Nick","family":"van Es","sequence":"additional","affiliation":[{"name":"Department of Vascular Medicine University of Amsterdam, Amsterdam UMC Location  Amsterdam the Netherlands"},{"name":"Pulmonary Hypertension and Thrombosis Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7796-4463","authenticated-orcid":false,"given":"Hugo","family":"ten Cate","sequence":"additional","affiliation":[{"name":"Thrombosis Expert Center Maastricht Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"Cardiovascular Research Institute Maastricht (CARIM), School for Cardiovascular Diseases Maastricht University Medical Center  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2578-1766","authenticated-orcid":false,"given":"Judith","family":"de Vos\u2010Geelen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Medical Oncology Maastricht University Medical Center  Maastricht the Netherlands"},{"name":"GROW\u2013Research Institute for Oncology &amp; 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