{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:40:20Z","timestamp":1792809620486,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103534"],"award-info":[{"award-number":["82103534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515220088"],"award-info":[{"award-number":["2025A1515220088"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epithelial ovarian cancer (EOC) frequently disseminates within the lipid\u2010rich peritoneal cavity, where tumor progression is accompanied by metabolic adaptations involving lipid utilization and mitochondrial function. Although these metabolic alterations are increasingly recognized as important features of EOC progression and peritoneal metastasis, the molecular factors linking mitochondrial\u2013lipid metabolic remodeling with aggressive tumor behavior remain incompletely characterized. We therefore integrated mitochondrial\u2010 and lipid metabolism\u2010related transcriptomic analyses to identify candidate regulators and further investigated the clinical and biological features associated with CDS2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven key genes associated with mitochondrial and lipid metabolism were identified in EOC through comprehensive bioinformatic analyses and were used to construct the MALRS prognostic model. Further integration of FIGO stage, histologic grade, and MALRS scores yielded a nomogram whose calibration plots showed good agreement between predicted and observed 1\u2010, 3\u2010, and 5\u2010year survival probabilities. Subsequent screening of these candidate genes in chemotherapy\u2010resistant datasets identified CDP\u2010diacylglycerol synthase 2 (CDS2) as the most consistently upregulated candidate gene. Clinical validation confirmed that CDS2 was significantly overexpressed in tumor tissues and was associated with advanced disease stage, and survival analysis showed that higher CDS2 expression was associated with shorter progression\u2010free survival (PFS) in stage III\/IV patients. Functional characterization demonstrated that CDS2 overexpression promoted both lipid droplet accumulation and migratory capacity in ovarian cancer cells. Pathway analysis identified significant enrichment of PI3K\/AKT signaling, and experimental validation confirmed CDS2\u2010mediated hyperactivation of PI3K\/AKT phosphorylation. Computational immune\u2010deconvolution analyses further identified exploratory associations between CDS2 expression, estimated T\u2010cell abundance, and immune\u2010checkpoint transcripts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CDS2 is a lipid metabolism\u2010associated candidate biomarker linked to aggressive clinicopathological features in EOC. Our findings associate CDS2 with disease progression, PI3K\/AKT\u2010related signaling, and immune\u2010related transcriptomic features, supporting its further evaluation as a candidate prognostic marker.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72309","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:12:44Z","timestamp":1792465964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CDS2 Drives Tumor Progression in Epithelial Ovarian Cancer via the PI3K\/AKT Pathway"],"prefix":"10.1002","volume":"15","author":[{"given":"Lixue","family":"Cao","sequence":"first","affiliation":[{"name":"Medical Research Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University  Guangzhou Guangdong 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