{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:59:44Z","timestamp":1790657984980,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Opioid use in pediatric oncology is poorly characterized. The primary objective was to describe opioid administration or prescription patterns in pediatric oncology patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this multi\u2010center retrospective study conducted across three sites, we included patients aged 0\u201319\u2009years with a malignant neoplastic disease who received their first chemotherapy between January 2019 and March 2024. Data were extracted from each site's Observational Medical Outcomes Partnership Common Data Model. We described patient characteristics based on: (1) first opioid administration or prescription, overall and for each specific opioid; and (2) all opioid administrations or prescriptions, overall and for each specific opioid. We also evaluated variability in opioid and naloxone use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 2903 pediatric patients with cancer, 2707 (93.2%) were administered or prescribed at least one opioid. Among these patients, fentanyl was the most common (92.4%), followed by morphine (68.7%), hydromorphone (55.3%), and oxycodone (38.6%). Across centers, the proportion of patients receiving fentanyl ranged from 90.9% to 94.9%, morphine from 34.0% to 89.2%, oxycodone from 0.9% to 76.1%, and naloxone from 2.4% to 29.5%. Overall, 10.9% were administered or prescribed naloxone, but among 169 methadone patients, 43.5% were administered or prescribed it. Of the 153,849 total opioid administrations or prescriptions, 22.4% occurred more than 12\u2009months after initiating chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among pediatric patients with cancer who receive chemotherapy, 93.2% were administered or prescribed at least one opioid; fentanyl was the most common. There was heterogeneity in opioid choice and naloxone use across sites. These findings lay preliminary groundwork for understanding opioid use patterns and identifying potential areas for practice improvement in pediatric oncology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72310","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:51:09Z","timestamp":1790657469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Center Evaluation of Opioid Administration or Prescription in Pediatric Oncology Patients Using the\n                    <scp>OMOP CDM<\/scp>"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9174-8935","authenticated-orcid":false,"given":"Yuqing","family":"Feng","sequence":"first","affiliation":[{"name":"Child Health Evaluative Sciences The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Yi","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C.","family":"Aftandilian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4058-1586","authenticated-orcid":false,"given":"Melissa P.","family":"Beauchemin","sequence":"additional","affiliation":[{"name":"Columbia University School of Nursing\/Herbert Irving Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-7355","authenticated-orcid":false,"given":"Christine","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"DeStephano","sequence":"additional","affiliation":[{"name":"Columbia University School of Nursing\/Herbert Irving Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5464-5548","authenticated-orcid":false,"given":"Rhea K.","family":"Khurana","sequence":"additional","affiliation":[{"name":"Columbia University School of Nursing\/Herbert Irving Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Larimer","sequence":"additional","affiliation":[{"name":"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Department of Pediatrics Seattle Children's Hospital, University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-3391","authenticated-orcid":false,"given":"Jennifer","family":"Oberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin L.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith","family":"Morse","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine  Palo Alto California USA"},{"name":"Stanford Center for Biomedical Informatics Research Stanford University  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-9431","authenticated-orcid":false,"given":"Karthik","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Data Sciences Unit Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3465-5000","authenticated-orcid":false,"given":"David","family":"Noyd","sequence":"additional","affiliation":[{"name":"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Department of Pediatrics Seattle Children's Hospital, University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0255-6344","authenticated-orcid":false,"given":"Victoria","family":"Soucek","sequence":"additional","affiliation":[{"name":"Ben Towne Center for Childhood Cancer and Blood Disorders Research, Department of Pediatrics Seattle Children's Hospital, University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-3095","authenticated-orcid":false,"given":"Adam","family":"Yan","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-8442","authenticated-orcid":false,"given":"Lin Lawrence","family":"Guo","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0951-3091","authenticated-orcid":false,"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Child Health Evaluative Sciences The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Division of Haematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1001\/jamapediatrics.2024.4727","article-title":"Symptom Screening for Hospitalized Pediatric Patients With Cancer: A Randomized Clinical Trial","volume":"179","author":"Dupuis L. L.","year":"2025","journal-title":"JAMA Pediatrics"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/jnci\/djx250","article-title":"Validation of the Symptom Screening in Pediatrics Tool in Children Receiving Cancer Treatments","volume":"110","author":"Dupuis L. L.","year":"2018","journal-title":"Journal of the National Cancer Institute"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1001\/jama.2024.19585","article-title":"Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial","volume":"332","author":"Dupuis L. L.","year":"2024","journal-title":"JAMA"},{"key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.ejca.2020.02.039","article-title":"Reducing Pain and Distress Related to Needle Procedures in Children With Cancer: A Clinical Practice Guideline","volume":"131","author":"Loeffen E. A. H.","year":"2020","journal-title":"European Journal of Cancer"},{"key":"e_1_2_11_6_1","first-page":"4521","article-title":"Opioid Use and Misuse in Children, Adolescents, and Young Adults With Cancer: A Systematic Review of the Literature","volume":"29","author":"Beauchemin M.","year":"2021","journal-title":"Support Care Cancer"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s40272-024-00654-6","article-title":"A Narrative Review of Pain in Pediatric Oncology: The Opioid Option for Procedural and Surgical Pain","volume":"27","author":"Hall E. A.","year":"2025","journal-title":"Paediatric Drugs"},{"key":"e_1_2_11_8_1","first-page":"574","article-title":"Observational Health Data Sciences and Informatics (OHDSI): Opportunities for Observational Researchers","volume":"216","author":"Hripcsak G.","year":"2015","journal-title":"Studies in Health Technology and Informatics"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21586","article-title":"Development and Validation of the SickKids Enterprise\u2010Wide Data in Azure Repository (SEDAR)","volume":"9","author":"Guo L. L.","year":"2023","journal-title":"Heliyon"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1002\/cncr.34238","article-title":"New Persistent Opioid Use Among Adolescents and Young Adults With Sarcoma","volume":"128","author":"Beauchemin M. P.","year":"2022","journal-title":"Cancer"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-019-0625-0","article-title":"The Rising Crisis of Illicit Fentanyl Use, Overdose, and Potential Therapeutic Strategies","volume":"9","author":"Han Y.","year":"2019","journal-title":"Translational Psychiatry"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1200\/JCO.22.02198","article-title":"Use of Opioids for Adults With Pain From Cancer or Cancer Treatment: ASCO Guideline","volume":"41","author":"Paice J. A.","year":"2023","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2024-068752","article-title":"Opioid Prescribing for Acute Pain Management in Children and Adolescents in Outpatient Settings: Clinical Practice Guideline","volume":"154","author":"Hadland S. E.","year":"2024","journal-title":"Pediatrics"},{"key":"e_1_2_11_14_1","volume-title":"Naloxone Best Practice Guideline","author":"(CRISM) CRIiSM","year":"2023"},{"key":"e_1_2_11_15_1","volume-title":"Naloxone Prescription Requirements"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72310","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:51:21Z","timestamp":1790657481000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cam4.72310"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72310","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72310"}}