{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:51:52Z","timestamp":1791265912643,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2021JJ41056"],"award-info":[{"award-number":["2021JJ41056"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multiple myeloma (MM) is an incurable hematologic malignancy, requiring sustained therapeutic management to mitigate disease recurrence. Ixazomib, a first\u2010generation oral proteasome inhibitor, has exhibited substantial clinical efficacy and is widely employed in clinical practice. According to prescribing guidelines, ixazomib is typically administered at an initial dose of 4\u2009mg weekly for 3\u2009weeks, with dose reduction to 3\u2009mg weekly in the event of adverse effects. Prior exposure\u2013response analyses have confirmed that both 3 and 4\u2009mg doses reside within the clinically effective range. This study aims to assess the comparative efficacy and toxicity profiles of 3 versus 4\u2009mg ixazomib in MM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of 207\u2009MM patients undergoing ixazomib\u2010based therapy across six medical centers. Patients were stratified into three subgroups: initial treatment, in\u2010class transition, and maintenance\/continuation therapy group. Additionally, patients were categorized into two cohorts according to ixazomib dosage: 3 or 4\u2009mg. Demographic characteristics, baseline clinical features, and therapeutic outcomes were compared between the 3 and 4\u2009mg cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results indicate that 3 and 4\u2009mg ixazomib demonstrate equivalent efficacy in induction, class\u2010switch, and maintenance\/continuation therapy across most clinical scenarios in Chinese MM patients. Subgroup analysis within the in\u2010class transition cohort revealed that patients with RISS Stage 3 disease exhibited prolonged progression\u2010free survival in the 4\u2009mg group. Furthermore, patients with an ECOG performance status of one to two achieved enhanced overall survival with the 4\u2009mg dose. The overall adverse event rates were comparable between the two dose groups. Notably, during the induction phase, the 4\u2009mg group exhibited a significantly higher incidence of Grades 1\u20132 vomiting (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that initiating therapy with 3\u2009mg ixazomib is both clinically viable and effective, potentially alleviating the economic burden for MM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72314","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:19:08Z","timestamp":1790230748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multicenter Retrospective Comparative Analysis of Therapeutic Outcomes in Multiple Myeloma Patients Receiving Varied Ixazomib Dosage Regimens"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-3711","authenticated-orcid":false,"given":"Liang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Hematology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Hematology Xiangya Hospital, Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Xiangya Hospital of Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Hematology Hunan University of Medicine General Hospital  Huaihua Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology Hunan University of Medicine General Hospital  Huaihua Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongqi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Hematology Hunan University of Medicine General Hospital  Huaihua Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youping","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University  Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanjuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology Zhuzhou Hospital Affiliated to Xiangya School of Medicine, Central South University  Zhuzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-8789","authenticated-orcid":false,"given":"Zhongjun","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Hematology Central Hospital of Xiangtan  Xiangtan Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-7686","authenticated-orcid":false,"given":"Zimian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology Central Hospital of Xiangtan  Xiangtan Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology Chenzhou First People's Hospital  Chenzhou Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology Chenzhou 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