{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:04:39Z","timestamp":1790838279168,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007186","name":"Jonsson Comprehensive Cancer Center, University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007186","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer\u2010related cognitive impairment (CRCI) is an increasingly recognized survivorship concern, yet its prevalence and associated clinical and psychosocial factors among survivors of head and neck cancer (HNC) remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross\u2010sectional study recruited survivors of HNC, who were at least 1\u2010year post\u2010diagnosis, from an institutional tumor registry to complete a comprehensive survey. Self\u2010reported cognitive function was assessed using the PROMIS Cognitive Function Short Form 8a, with a\n                      <jats:italic>T<\/jats:italic>\n                      \u2010score\u2009&lt;\u200940 indicating cognitive impairment. Symptom burden was assessed using the EORTC QLQ\u2010HN43, PROMIS short forms, and the Insomnia Severity Index. Social role functioning was assessed using the PROMIS Satisfaction with Participation in Social Roles short form. Multivariable linear and logistic regression examined factors independently associated with self\u2010reported cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 337 survey respondents, 41 survivors (12.2%) met criteria for self\u2010reported moderate to severe cognitive impairment. Cognitively impaired survivors reported significantly higher symptom burden and lower social role functioning than survivors within normal limits. In multivariable linear regression (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.520), poorer cognitive function was significantly associated with anxiety (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.362,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), fatigue (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.223,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), sleep disturbance (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.261,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and social isolation (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.178,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). In logistic regression, anxiety (OR\u2009=\u20091.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035), fatigue (OR\u2009=\u20091.08,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.021), and high\u2010intensity treatment (OR\u2009=\u20092.62,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028) were independently associated with impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Approximately one in eight HNC survivors reported moderate\u2010to\u2010severe cognitive impairment. Self\u2010reported cognitive difficulty was associated with psychosocial symptom burden and multimodal treatment, and co\u2010occurred with poorer social role functioning. These findings support concurrent assessment of cognitive and psychosocial symptoms in HNC survivorship care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72316","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:49:56Z","timestamp":1790837396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Reported Cancer\u2010Related Cognitive Impairment and Psychosocial Symptom Burden in Survivors of Head and Neck Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-9670","authenticated-orcid":false,"given":"Matthew E.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Stenzel","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery David Geffen School of Medicine at University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-6363","authenticated-orcid":false,"given":"Desiree","family":"Delavary","sequence":"additional","affiliation":[{"name":"A.T. Still University School of Osteopathic Medicine  Mesa Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maie A.","family":"St. John","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Johns Hopkins Medicine  Baltimore Maryland USA"},{"name":"Multidisciplinary Head and Neck Cancer Program UCLA Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Multidisciplinary Head and Neck Cancer Program UCLA Health  Los Angeles California USA"},{"name":"Department of Medicine, David Geffen School of Medicine at UCLA University of California, Los Angeles (UCLA)  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1841-4143","authenticated-orcid":false,"given":"Patricia A.","family":"Ganz","sequence":"additional","affiliation":[{"name":"Department of Medicine, David Geffen School of Medicine at UCLA University of California, Los Angeles (UCLA)  Los Angeles California USA"},{"name":"Department of Health Policy and Management, Fielding School of Public Health University of California, Los Angeles (UCLA)  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-1748","authenticated-orcid":false,"given":"Eden R.","family":"Brauer","sequence":"additional","affiliation":[{"name":"Multidisciplinary Head and Neck Cancer Program UCLA Health  Los Angeles California USA"},{"name":"Joe C. 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