{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T23:02:56Z","timestamp":1791932576011,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270205"],"award-info":[{"award-number":["82270205"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Comparative investigations evaluating the efficacy of pomalidomide\u2010based (Pom\u2010based) versus daratumumab\u2010based (Dara\u2010based) therapies in patients with relapsed\/refractory multiple myeloma (RRMM) remain scarce, both in randomized controlled trials and real\u2010world studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included 140 RRMM patients treated with Pom\u2010based or Dara\u2010based or a combination of pomalidomide and daratumumab (DPd) regimens in a Chinese tertiary hospital between December 2018 and July 2023.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall response rates (ORR) for Pom\u2010based (<jats:italic>n<\/jats:italic>\u2009=\u200948), Dara\u2010based (<jats:italic>n<\/jats:italic>\u2009=\u200968), and DPd (<jats:italic>n<\/jats:italic>\u2009=\u200924) groups were 57.8%, 84.6%, and 75.0%, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.007). At data cutoff on August 1, 2023, the median progression\u2010free survival (PFS) was 5.7\u2009months (95% CI: 5.0\u20136.5) for the Pom\u2010based group, 10.5\u2009months (5.2\u201315.8) for the Dara\u2010based group, and 6.7\u2009months (4.0\u20139.3) for the DPd group (<jats:italic>p\u2009=<\/jats:italic>\u20090.056). Multivariate analysis identified treatment regimens (Dara\u2010based vs. Pom\u2010based, DPd vs. Pom\u2010based) and Eastern Cooperative Oncology Group performance status (ECOG PS) as independent prognostic factors for PFS. In the subgroups of patients aged &gt;65\u2009years, with ECOG PS \u22652, lines of therapy \u22652, extramedullary disease or double\u2010refractory disease (refractory to both lenalidomide and proteasome inhibitors), the superiority of Dara\u2010based regimens over Pom\u2010based regimens was not evident. A higher incidence of infections was observed in patients receiving Dara\u2010based and DPd regimens (Pom\u2010based 39.6% vs. Dara\u2010based 64.7% vs. DPd 70.8%, <jats:italic>p\u2009=<\/jats:italic>\u20090.009).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In real\u2010world settings, Pom\u2010based, Dara\u2010based, and DPd therapies exhibited favorable efficacy in patients with RRMM. Dara\u2010based therapy yielded superior clinical response and PFS compared to Pom\u2010based therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7232","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T06:20:41Z","timestamp":1714717241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical outcomes of pomalidomide\u2010based and daratumumab\u2010based therapies in patients with relapsed\/refractory multiple myeloma: A real\u2010world cohort study in China"],"prefix":"10.1002","volume":"13","author":[{"given":"Xiaoyan","family":"Han","sequence":"first","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Center The First Affiliated Hospital, School of Medicine, Zhejiang University  Hangzhou Zhejiang 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