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However, real\u2010world data on treatment patterns and outcomes, particularly among high\u2010risk subgroups, remain limited. The CHAMP\u2010MM study aimed to evaluate real\u2010world frontline and post\u2010initial relapse treatment patterns and outcomes in NDMM patients, including high\u2010risk subgroups, defined as those age \u2265\u200965 (elderly), with renal impairment (RI), and with 1q cytogenetic abnormalities. The study utilized electronic medical record data from five tertiary hematologic centers in China. Adult patients diagnosed with active MM between 2018 and 2022 were included and followed until last visit or end of study (December 31, 2023). A total of 1139 patients were analyzed, including 364 elderly, 148 with RI, and 334 with 1q abnormalities. PI+IMiD\u2010based regimens were the most common frontline therapy (50.0%) overall, as well as in elderly patients and 1q subgroups, whereas PI\u2010based regimens were more frequently used in RI patients. Only 25.1% of NDMM patients received autologous stem cell transplant after induction. Following initial relapse, PI+IMiD\u2010based (32.6%) and CD38\u2010based (30.9%) regimens predominated. Frontline overall response rates were approximately 80% across all groups, whereas the proportion of patients achieving very good partial response (PR) or better ranged from 60.9% to 75.1% across subgroups. While overall 12\u2010 and 24\u2010month progression\u2010free survival (PFS) rates remained high, outcomes were poorer in high\u2010risk subgroups. This study reflects real\u2010world treatment trends in China over 5\u2009years and emphasizes the continued need for tailored treatment approaches in high\u2010risk populations.<\/jats:p>","DOI":"10.1002\/cam4.72332","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:15:11Z","timestamp":1790759711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Patterns and Clinical Outcomes Among Chinese Patients With Newly Diagnosed Multiple Myeloma: A Multicenter Retrospective Study (\n                    <scp>CHAMP<\/scp>\n                    \u2010\n                    <scp>MM<\/scp>\n                    )"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3885-6782","authenticated-orcid":false,"given":"Jian","family":"Cui","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical 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