{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:25Z","timestamp":1791352225719,"version":"4.3.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Immune\u2010related adverse events (irAEs) are complications associated with immune checkpoint inhibitors (ICIs). Hematologic irAEs (heme\u2010irAEs) are rare but potentially serious and may interfere with cancer treatment. However, their clinical characteristics remain insufficiently described.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective study using the National Cancer Center Hospital East medical database from April 1, 2014, to March 31, 2024. Potential heme\u2010irAE cases were identified using diagnostic name searches, bone marrow examination records, and positive DAT results and were followed by chart review to exclude alternative etiologies, such as chemotherapy\u2010related myelosuppression, marrow involvement, infection, and hematologic malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 3371 patients treated with ICI\u2010containing regimens, 40 patients developed heme\u2010irAEs, indicating an observed incidence of 1.2%. The most common heme\u2010irAE reported was immune thrombocytopenia, and 85.0% of these events were Grade 3 or higher. The median time from ICI initiation to heme\u2010irAE onset was 12\u2009weeks. For all affected patients included in the regimen\u2010specific onset\u2010time comparison, the median time to heme\u2010irAE onset appeared shorter with dual ICI therapy without chemotherapy than with ICI monotherapy, although this descriptive comparison was based on a small number of cases. ICI\u2010containing regimens were interrupted or discontinued in most patients, and systemic corticosteroids were administered to 25 patients, 18 of whom achieved hematologic improvement. Cancer treatment was resumed or continued for 20 patients, with no recurrent heme\u2010irAEs observed during the follow\u2010up period. In an exploratory landmark analysis, hematologic response was associated with longer survival after heme\u2010irAE onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Heme\u2010irAEs were rare but frequently severe in this Japanese single\u2010center cohort. Their occurrence was associated with prolonged interruption of cancer treatment, underscoring the importance of early recognition, careful diagnostic evaluation, and multidisciplinary management of heme\u2010irAEs. Our findings regarding dual ICI therapy, survival, and subsequent ICI therapy after heme\u2010irAE onset should be interpreted as exploratory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72337","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:57:43Z","timestamp":1791349063000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence, Clinical Characteristics, Management, and Outcomes of Hematologic Immune\u2010Related Adverse Events Associated With Immune Checkpoint Inhibitors: A Single\u2010Center Japanese Retrospective Cohort Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3187-5114","authenticated-orcid":false,"given":"Ryo","family":"Yoshimaru","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology National Cancer Center Hospital East  Kashiwa 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