{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:04:20Z","timestamp":1790751860349,"version":"4.1.0"},"reference-count":70,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R03CA273489"],"award-info":[{"award-number":["R03CA273489"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["T32CA261787"],"award-info":[{"award-number":["T32CA261787"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Quality of life (QoL) is important for patients with metastatic breast cancer (MBC). We examined QoL in daily life among patients with MBC using ecological momentary assessment (EMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 2023 to 2024, patients with MBC were recruited from 5 Mid\u2010Atlantic sites. Eligible patients were English\u2010 or Spanish\u2010speaking, with a life expectancy &gt;\u20096\u2009months and access to a smartphone. Participants were invited to complete 12 EMAs over 4\u2009weeks. EMAs assessed global QoL, symptom severity (depression, anxiety, pain, fatigue, slowed cognition, appetite loss, nausea, gastrointestinal distress, decreased libido), and positive affect (social connection, peace, joy). Multilevel mixed\u2010effects models analyzed the relationships between QoL and between\u2010person and within\u2010person variations in symptom severity and positive affect. We also explored associations between QoL and years since MBC diagnosis at the time of study entry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u2009108; Mean age 57.8\u2009years) were a mean of 4.4\u2009years post\u2010diagnosis (range\u2009=\u20090.06\u201320.65\u2009years). Between\u2010person effects indicated QoL was worse among individuals reporting more nausea (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.109,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035) and less joy (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.593,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Within\u2010person effects indicated individuals' QoL was lower at times when they had more depression (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.177,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), anxiety (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.049,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023), fatigue (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.052,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009), appetite loss (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.053,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028), and decreased libido (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.058,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) and less social connectedness (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.091,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), joy (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.055,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.047), and peace (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.107,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) than their personal average. QoL was not associated with years since MBC diagnosis (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.106,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.956). Age (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20090.482,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013) and being partnered (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u200913.356,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) at baseline were positively associated with estimated QoL at MBC diagnosis. Changes in QoL per year since MBC diagnosis were positively associated with being employed at baseline (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u20092.453,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and negatively associated with HR positive disease (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22121.334,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both within\u2010person and between\u2010person variations in symptom severity and positive affect are associated with QoL, highlighting the need for adaptive, targeted intervention strategies to optimize QoL for all patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72338","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:43:47Z","timestamp":1790750627000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life in Adults With Metastatic Breast Cancer: The Impact of Between\u2010 and Within\u2010Person Changes in Symptoms and Positive Affect"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-111X","authenticated-orcid":false,"given":"Brenna","family":"Mossman","sequence":"first","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-4689","authenticated-orcid":false,"given":"Brent J.","family":"Small","sequence":"additional","affiliation":[{"name":"School of Nursing University of North Carolina 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D.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aigner","family":"Bobbitt","sequence":"additional","affiliation":[{"name":"John Theurer Cancer Center Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alene","family":"Mathurin","sequence":"additional","affiliation":[{"name":"John Theurer Cancer Center Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Glenn","sequence":"additional","affiliation":[{"name":"Patient Author, Project Life Metastatic Breast Cancer  Calabasas California 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3846-5052","authenticated-orcid":false,"given":"Christopher","family":"Gallagher","sequence":"additional","affiliation":[{"name":"MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deena","family":"Graham","sequence":"additional","affiliation":[{"name":"John Theurer Cancer Center Hackensack University Medical Center  Hackensack New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-396X","authenticated-orcid":false,"given":"Nina","family":"Kadan\u2010Lottick","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne C.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-2428","authenticated-orcid":false,"given":"Claire C.","family":"Conley","sequence":"additional","affiliation":[{"name":"Lombardi Comprehensive Cancer Center Georgetown University  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"5","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2026.12042","article-title":"Stage IV Breast Cancer Incidence and Survival, 2010\u20132021","volume":"9","author":"Avila J.","year":"2026","journal-title":"JAMA Network 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