{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:56:38Z","timestamp":1791266198529,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the perioperative changes in inflammatory\u2013immune\u2013nutritional indicators in patients with advanced gallbladder cancer (GBC), defined as American Joint Committee on Cancer (AJCC) Stage III\u2013IV, and to assess whether individual indicators provide incremental prognostic information beyond conventional clinicopathological factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with pathologically confirmed advanced GBC who underwent surgery at the Department of Hepatobiliary Surgery, National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, between 2010 and 2022 were retrospectively enrolled. Preoperative and postoperative Day 7 values of the albumin\u2010to\u2010alkaline phosphatase ratio (AAPR), albumin\u2010to\u2010globulin ratio (AGR), albumin\u2013bilirubin score (ALBI), advanced lung cancer inflammation index (ALI), monocyte\u2010to\u2010lymphocyte ratio (MLR), neutrophil\u2010to\u2010lymphocyte ratio (NLR), prognostic nutritional index (PNI), and systemic inflammation response index (SIRI) were calculated. Perioperative dynamic changes were compared, and Cox proportional hazards models were constructed to evaluate the incremental prognostic value of these indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 103 patients with advanced GBC, all eight inflammatory\u2013immune\u2013nutritional indicators showed significant changes between the preoperative period and postoperative Day 7. Several preoperative and postoperative indicators were associated with cancer\u2010specific survival (CSS) in cutoff\u2010based exploratory analyses. After the incorporation of these indicators into clinicopathological models, most extended models showed varying degrees of improvement in discrimination and goodness of fit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this single\u2010center cohort, perioperative inflammatory\u2013immune\u2013nutritional indicators exhibit significant dynamic changes in advanced GBC and can improve, to a certain extent, the prognostic performance of models based on conventional clinicopathological characteristics. These indicators may serve as useful supplementary tools for risk stratification and individualized prognostic assessment in patients with advanced GBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72351","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:40:52Z","timestamp":1791265252000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Perioperative Inflammatory\u2013Immune\u2013Nutritional Indicators in Advanced Gallbladder Cancer"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4219-8456","authenticated-orcid":false,"given":"Rongxuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9797-9437","authenticated-orcid":false,"given":"Bingchen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayong","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1068-7617","authenticated-orcid":false,"given":"Jianguo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082073"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.10.014"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071686"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010022\u201002091\u20106"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.09.004"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/hpb.12444"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.12.029"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21683"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2019.08.13"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2010.02.011"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010020\u201008858\u2010z"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010022\u201000398\u2010y"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.27875"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009\u20100302"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1678446"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.10.002"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2020.303"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010024\u201003374\u2010w"},{"key":"e_1_2_14_22_1","first-page":"485","article-title":"Perineural Infiltration as a Prognostic Factor in Surgically Treated Gallbladder Cancer A Single Center Experience and Literature Review","volume":"88","author":"Feo C. 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