{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:44:01Z","timestamp":1792143841948,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>We previously developed multiple machine\u2010learning and regression\u2010based risk prediction models using retrospective electronic health records (EHR) to estimate near\u2010term risk of pancreatic cancer (PC). This pilot study aimed to assess the feasibility of an early detection strategy combining initial EHR\u2010based risk prediction with downstream imaging and blood\u2010based testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study included adults aged 50\u201384\u2009years with an estimated \u2265\u20091% 18\u2010month risk of PC, identified between January 2021 and March 2023 using four previously validated models. Patients with a history or active suspicion of PC were excluded. Participants completed cross\u2010sectional imaging and CA19\u20109 Labs at baseline and again at 18\u2009months. Outcomes included enrollment rates, test completion rate, and burden of incidental findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1251 eligible patients, 102 (8.2%) enrolled (median age 69\u2009years [IQR 62\u201375]; 58% women; 48% Hispanic, 34% White, 11% Black, and 7% Asian). At baseline, 89 (87%) completed imaging and 98 (96%) completed CA19\u20109. At 18\u2009months, 79% completed both imaging and CA19\u20109. Ten (10%) participants underwent additional clinical evaluations triggered by imaging findings. Evaluations included an endoscopic ultrasound, renal imaging, and FibroScan. CA19\u20109 results were normal in most participants, though 18% had elevated levels at baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Real\u2010time EHR\u2010based ML algorithms can be combined with blood\u2010 and imaging\u2010based surveillance for early detection of PC with acceptable burden of incidental findings. However, improved patient engagement is a key aspect that will need to be addressed in order to successfully scale an AI\u2010guided strategy for early detection.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72368","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:45:16Z","timestamp":1792140316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of Risk Prediction Models Using Electronic Health Data for Early Detection of Pancreatic Cancer: A Prospective Pilot Feasibility Study"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3304-2704","authenticated-orcid":false,"given":"Bechien U.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Research and Evaluation Southern California Permanente Medical Group  Pasadena California USA"},{"name":"Department of Gastroenterology Kaiser Permanente Los Angeles Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-9248","authenticated-orcid":false,"given":"Tiffany Q.","family":"Luong","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Southern California Permanente Medical Group  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6719-6090","authenticated-orcid":false,"given":"Eva","family":"Lustigova","sequence":"additional","affiliation":[{"name":"Tulane Center for Clinical Research Tulane University School of Medicine  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christie","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Epidemiology UCLA Fielding School of Public Health  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3963-314X","authenticated-orcid":false,"given":"Eric J.","family":"Puttock","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Southern California Permanente Medical Group  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7463-1743","authenticated-orcid":false,"given":"Rebecca H.","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Kaiser Permanente Los Angeles Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes A.","family":"Munis","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Southern California Permanente Medical Group  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-7468","authenticated-orcid":false,"given":"Wansu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Research and Evaluation Southern California Permanente Medical Group  Pasadena California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"National Cancer Institute Surveillance Epidemiology and End Results Program \u201cCancer Stat Facts: Pancreatic Cancer \u201dhttps:\/\/seer.cancer.gov\/statfacts\/html\/pancreas.html."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10232"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002870"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002022"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2196\/44248"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002332\u20105"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000002050"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.05.023"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620\u2010020\u201006139\u2010z"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000002000"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djaf291"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001772\u20109"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2023.04.009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.232007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.4989"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.14309\/ctg.0000000000000468"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.03.016"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.1.114"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz137"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2026.0493"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.17864"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.72368","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.72368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:45:18Z","timestamp":1792140318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.72368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/cam4.72368"],"URL":"https:\/\/doi.org\/10.1002\/cam4.72368","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72368"}}