{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:58Z","timestamp":1792809538304,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["TYH2022329"],"award-info":[{"award-number":["TYH2022329"]}],"id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>New\u2010onset diabetes (NOD) potentially associated with pancreatic cancer (PC) requires further investigation to assess its potential as a tool for PC screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>In this longitudinal nationwide register study, which includes 14,712 PC patients and 18\u2009years of follow\u2010up time (2000\u20132018), we aimed to assess the prevalence of diabetes by using a large national registry. Survival was analyzed according to diabetes status and duration (long\u2010term diabetes, i.e., DM diagnosed &gt;\u20093\u2009years prior to PC, NOD, i.e., DM diagnosed 0\u20133\u2009years prior to PC, or DM diagnosed after PC diagnosis) and treatment status (curative intent vs. palliative) using multivariable Cox regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 18% of PC patients had diabetes. The median time interval between DM and PC diagnoses was 4.8\u2009months. In the multivariable Cox regression analysis, only DM diagnosed after PC was associated with worse survival, both in the palliative intent treatment group (HR 1.12, 95% CI 1.03\u20131.23,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011) and in the curative intent treatment group (HR 1.44, 95% CI 1.14\u20131.81,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). Among patients diagnosed with diabetes prior to PC, neither long\u2010term nor NOD significantly affected survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most of the diabetic PC\u2010patients have been diagnosed with DM within a close proximity of cancer diagnosis. The progression from diabetes to clinically detectable cancer seems to be rapid\u2014less than 6\u2009months. Given the aggressive nature of PC and the fact that NOD can be an early sign, screening may need to begin at the time of diabetes diagnosis. The fact that a DM diagnosis made after a PC diagnosis is associated with worse survival may suggest that pancreatic tumors that cause hyperglycemia are particularly aggressive.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72380","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:10:48Z","timestamp":1792462248000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diabetes Among Finnish Pancreatic Cancer Patients: Prevalence, Time Interval Between Diabetes and Cancer Diagnosis, and Overall Survival"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6472-7004","authenticated-orcid":false,"given":"Suitiala","family":"Roosa","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery University of Helsinki and Helsinki University Hospital  Helsinki 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and Helsinki University Hospital  Helsinki Finland"},{"name":"Department of Diagnostics and Intervention\/Surgery Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepp\u00e4nen","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery University of Helsinki and Helsinki University Hospital  Helsinki Finland"},{"name":"Translational Cancer Medicine Research Program, iCAN Digital Precision Cancer Medicine Flagship, Faculty of Medicine University of Helsinki  Helsinki 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