{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:56:40Z","timestamp":1787849800891,"version":"build-2784847793"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several clinical prognostic models for diffuse large B\u2010cell lymphoma (DLBCL) have been proposed, including the most commonly used International Prognostic Index (IPI), the National Comprehensive Cancer Network IPI (NCCN\u2010IPI), and models incorporating beta\u20102 microglobulin (\u03b22M). However, the role of \u03b22M in DLBCL patients is not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We identified 6075 patients with newly diagnosed DLBCL treated with immunochemotherapy registered in the Danish Lymphoma Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 3232 patients had data available to calculate risk scores from each of the nine considered risk models for DLBCL, including a model developed from our population. Three of four models with \u03b22M and NCCN\u2010IPI performed better than the International Prognostic Indexes (IPI, age\u2010adjusted IPI, and revised IPI). Five\u2010year overall survival for high\u2010 and low\u2010risk patients were 43.6% and 86.4% for IPI and 34.9% and 96.2% for NCCN\u2010IPI. In univariate analysis, higher levels of \u03b22M were associated with inferior survival, higher tumor burden (advanced clinical stage and bulky disease), previous malignancy and increased age, and creatinine levels. Furthermore, we developed a model (\u03b22M\u2010NCCN\u2010IPI) by adding \u03b22M to NCCN\u2010IPI (c\u2010index 0.708) with improved discriminatory ability compared to NCCN\u2010IPI (c\u2010index 0.698,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and 5\u2010year OS of 33.1%, 56.2%, 82.4%, and 96.4% in the high, high\u2010intermediate, low\u2010intermediate and low\u2010risk group, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>International Prognostic Indices, except for NCCN\u2010IPI, fail to accurately discriminate risk groups in the rituximab era. \u03b22M, a readily available marker, could improve the discriminatory performance of NCCN\u2010IPI and should be re\u2010evaluated in the development setting of future models for DLBCL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7239","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T08:58:54Z","timestamp":1718701134000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Revisiting beta\u20102 microglobulin as a prognostic marker in diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-8539","authenticated-orcid":false,"given":"Jelena","family":"Jelicic","sequence":"first","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Juul\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Hematology Odense University Hospital  Odense 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