{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:39:04Z","timestamp":1792809544696,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372972"],"award-info":[{"award-number":["82372972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403386"],"award-info":[{"award-number":["82403386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most patients with hypopharyngeal squamous cell carcinoma (HPSCC) achieve partial response (PR) after induction chemotherapy. However, optimal post\u2010induction management remains controversial. We compared survival outcomes of post\u2010induction strategies for PR\u2010HPSCC, with emphasis on advanced post\u2010induction tumor stage (ycT) using inverse probability of treatment weighting (IPTW\u2010ATO) to mitigate confounding by indication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This retrospective study included 149 patients with PR\u2010HPSCC after induction chemotherapy who subsequently received surgery\u2010based therapy (SBT;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200971) or definitive chemoradiotherapy (CRT;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200978). IPTW\u2010ATO was used to address covariate imbalances between groups. Overall survival (OS) and progression\u2010free survival (PFS) were evaluated using weighted Kaplan\u2013Meier analyses and IPTW\u2010ATO\u2010adjusted Cox proportional hazards models. Sensitivity analyses compared findings across unadjusted, multivariable, and propensity score\u2010weighted models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In unadjusted analyses, OS and PFS did not differ significantly between groups. After IPTW\u2010ATO adjustment, SBT was associated with improved OS and PFS versus CRT. Exploratory subgroup analyses suggested a potential differential treatment effect across ycT strata; however, interaction tests were not statistically significant, and no significant survival difference was observed in patients with early ycT disease. In multivariable analyses, thyroid invasion was independently associated with worse OS, whereas anti\u2010PD\u20101 therapy was associated with improved OS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Outcomes among patients with PR\u2010HPSCC are heterogeneous. After adjustment for covariate imbalances, SBT was associated with favorable survival. These findings suggest that PR should not be treated as a uniform entity and that post\u2010induction ycT classification may help stratify patients for future prospective evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.72400","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T08:34:32Z","timestamp":1792139672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Outcomes of Post\u2010Induction Treatment Strategies in Patients With Partial Response Hypopharyngeal Squamous Cell Carcinoma: A Propensity Score\u2010Weighted Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6944-2507","authenticated-orcid":false,"given":"Hui\u2010Ching","family":"Lau","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Eye &amp; ENT Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Clinical Disciplines of Otorhinolaryngology  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eye &amp; ENT Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Clinical Disciplines of Otorhinolaryngology  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Key Clinical Disciplines of Otorhinolaryngology  Shanghai People's Republic of China"},{"name":"Department of Radiation Oncology Eye &amp; ENT Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-6252","authenticated-orcid":false,"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Clinical Disciplines of Otorhinolaryngology  Shanghai People's Republic of China"},{"name":"Department of Radiation Oncology Eye &amp; ENT Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eye &amp; ENT Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Clinical Disciplines of Otorhinolaryngology  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5771-1221","authenticated-orcid":false,"given":"Zhenwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eye &amp; ENT Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Clinical Disciplines of Otorhinolaryngology  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-7098","authenticated-orcid":false,"given":"Chi\u2010Yao","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eye &amp; ENT Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Clinical Disciplines of Otorhinolaryngology  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-8446","authenticated-orcid":false,"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Eye &amp; 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