{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:31:45Z","timestamp":1785252705468,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Obesity and hypercholesterolemia are linked to unfavor clinical outcomes. Recent studies declared the paradox that high body mass index (BMI) and serum cholesterol were independently connected to better clinical outcome of immune checkpoint inhibitors (ICIs) monotherapy in non\u2010small cell lung cancer (NSCLC). The aim of the study is to investigate the prognosis of BMI and serum cholesterol in ICIs\u2010based therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study of 95 NSCLC patients treated with ICIs\u2010based therapy at the Department of Oncology and Lung Cancer Center of China\u2010Japan Friendship Hospital. Treatment efficacy was assessed using durable clinical benefit (DCB) versus nondurable benefit (NDB), best response (active vs. nonactive), and progression\u2010free survival (PFS). The prognostic value of BMI, LDL\u2010C, and RC was determined by multivariate regression analyses, while controlling for confounding factors including age, gender, diabetes status, smoking history, and statin usage. BMI was considered a confounding factor in the analysis when examining the impact of lipoproteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our study, we found that in the whole group, BMI \u226525\u2009kg\/m<jats:sup>2<\/jats:sup> was linked to a higher risk of poor therapeutic response (OR\u2009=\u20095.92, 95% CI 1.99\u201319.51, <jats:italic>p<\/jats:italic>.val\u2009=\u20090.002) and shorter progression\u2010free survival (HR\u2009=\u20093.00, 95% CI 1.59\u20135.68, <jats:italic>p<\/jats:italic>.val\u2009=\u20090.001). In addition, low levels of RC were associated with better therapeutic response (OR\u2009=\u20090.12, 95% CI 0.02\u20130.64, <jats:italic>p<\/jats:italic>.val\u2009=\u20090.019), while low levels of serum LDL\u2010C were found to predict longer PFS (HR\u2009=\u20090.40, 95% CI 0.19\u20130.82, <jats:italic>p<\/jats:italic>.val\u2009=\u20090.012). These associations were consistent in advanced NSCLC patients receiving ICIs and chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggest that BMI \u226525\u2009kg\/m<jats:sup>2<\/jats:sup> and elevated levels of apoB\u2010containing lipoproteins, including LDL\u2010C and RC, could potentially serve as useful prognostic markers for predicting poor treatment outcomes in advanced NSCLC patients treated with the combination of chemotherapy and ICIs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7241","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T12:34:12Z","timestamp":1717158852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of body mass index and cholesterol\u2010rich <scp>apolipoprotein\u2010B<\/scp>\u2010containing lipoproteins on clinical outcome in <scp>NSCLC<\/scp> patients treated with immune checkpoint inhibitors\u2010based therapy: A retrospective analysis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-9451","authenticated-orcid":false,"given":"Zixin","family":"Hu","sequence":"first","affiliation":[{"name":"Beijing Hospital of Traditional Chinese Medicine Capital Medical University  Beijing China"},{"name":"Department of Oncology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oncology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Oncology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of National Integrated Traditional and Western Medicine Centre for Cardiovascular Disease China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangquan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of National Integrated Traditional and Western Medicine Centre for Cardiovascular Disease China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhening","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oncology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2900-0461","authenticated-orcid":false,"given":"Huijuan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Oncology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030320"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33270"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.04.013"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.010"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1852872"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2020.105876"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001403"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4220"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004374"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.029"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000330"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8180424"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-02979-4"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12050716"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1957605"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.3384"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14417"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107923"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-21-460"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2023.02.010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13236109"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.12.031"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000321"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.04.002"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-021-00826-6"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002474"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-018-2379-0"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-023-03522-3"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084288"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01965-2"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.947756"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T12:18:42Z","timestamp":1719577122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.7241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/cam4.7241"],"URL":"https:\/\/doi.org\/10.1002\/cam4.7241","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]},"assertion":[{"value":"2023-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7241"}}