{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:13:05Z","timestamp":1790046785625,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asparaginase is essential for treating T\u2010cell acute lymphoblastic leukemia (T\u2010ALL). Despite the ongoing debate on whether T\u2010ALL and T\u2010cell lymphoblastic lymphoma (T\u2010LBL) are the same disease entity or two distinct diseases, patients with T\u2010LBL often receive the same or similar treatment protocols as those with T\u2010ALL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The outcomes of patients with or without L\u2010asparaginase discontinuation were retrospectively analyzed among four national protocols: Japan Association of Childhood Leukemia Study (JACLS) ALL\u201002 and ALL\u201097 for T\u2010ALL and Japanese Pediatric Leukemia\/Lymphoma Study Group ALB\u2010NHL03 and JACLS NHL\u201098 for T\u2010LBL. The hazard ratio (HR) was calculated with the Cox regression model by considering L\u2010asparaginase discontinuation as a time\u2010dependent variable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 199 patients with T\u2010ALL, and 133 patients with T\u2010LBL were included. L\u2010asparaginase discontinuation compromised event\u2010free survival (EFS) of T\u2010ALL patients (ALL\u201002: HR 3.32, 95% confidence interval [CI] 1.40\u20137.90; ALL\u201097: HR 3.39, 95%CI 1.19\u20139.67). Conversely, EFS compromise was not detected among T\u2010LBL patients (ALB\u2010NHL03: HR 1.39, 95%CI 0.41\u20134.68; NHL\u201098: HR 0.92, 95%CI 0.11\u20137.60).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The effects of L\u2010asparaginase discontinuation differed between T\u2010ALL and T\u2010LBL. We assume that the differential impact results from (1) the inherent differential response to L\u2010asparaginase between them and\/or (2) a less stringent assessment of early treatment response in T\u2010LBL than in T\u2010ALL. Given the poor salvage rate of refractory or relapsed T\u2010ALL and T\u2010LBL, optimization of the frontline therapy is critical, and the current study provides a new suggestion for further treatment modifications. However, larger studies in contemporary intensified treatment protocols are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7246","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T09:07:13Z","timestamp":1718701633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Differential impact of asparaginase discontinuation on outcomes of children with T\u2010cell acute lymphoblastic leukemia and T\u2010cell lymphoblastic lymphoma"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3391-8403","authenticated-orcid":false,"given":"Hisashi","family":"Ishida","sequence":"first","affiliation":[{"name":"Department of Pediatrics Okayama University Hospital  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of 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