{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:17:09Z","timestamp":1789510629251,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["NU58DP006332"],"award-info":[{"award-number":["NU58DP006332"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN26100002"],"award-info":[{"award-number":["HHSN26100002"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["HHSN261201800007I"],"award-info":[{"award-number":["HHSN261201800007I"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aim to determine the effect of region of residence (urban vs. rural) on the odds of receiving standard of care treatment for locally advanced BCa in Louisiana and its impact on survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using the Louisiana Tumor Registry, we identified American Joint Committee on Cancer (AJCC) stage II or III, BCa diagnoses in Louisiana residents between 2010 and 2020. Treatment received was classified as standard or non\u2010standard of care according to American Urological Association (AUA) guidelines and location of residence was determined using Rural Urban Commuting Area\u2010Tract\u2010level 2010 (RUCA). Multivariable logistic regression analyses and multivariate cox proportional hazard analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 983 eligible patients, 85.6% (841\/983) lived in urban areas. Overall, only 37.5% received standard\u2010of\u2010care (SOC) for the definitive management of locally advanced bladder cancer. Individuals living in rural areas (OR 0.53, 95% CI: 0.31\u20130.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02) were less likely to receive standard of care treatment. Both rural residence and receipt of non\u2010standard of care therapy were associated with an increased risk of bladder cancer\u2010specific (adj HR 1.53, 95% CI: 1.09\u20132.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01 and adj HR: 1.85, 95% CI: 1.43\u20132.39, &lt;0.0001) and overall mortality (adj HR: 1.28, 95% CI: 1.01\u20131.61,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04 and adj HR: 1.73 95% CI: 1.44\u20132.07,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most patients with locally advanced bladder cancer in Louisiana do not receive SOC therapy. Individuals living in rural locations are more likely to receive non\u2010standard of care therapy than individuals in urban areas. Nonstandard of care treatment and rural residence are both associated with worse survival outcomes for Louisiana residents with locally advanced bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7301","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T01:41:25Z","timestamp":1719366085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of rural location on receipt of standard of care treatment and survival for locally advanced bladder cancer in Louisiana"],"prefix":"10.1002","volume":"13","author":[{"given":"Megan","family":"Escott","sequence":"first","affiliation":[{"name":"School of Medicine LSU Health Science Center  New Orleans Louisiana USA"},{"name":"Department of Urology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yi","sequence":"additional","affiliation":[{"name":"Louisiana Tumor Registry and Epidemiology  New Orleans Louisiana USA"},{"name":"School of Public Health LSU Health Science Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8034-7748","authenticated-orcid":false,"given":"Ashley","family":"Foret","sequence":"additional","affiliation":[{"name":"School of Medicine LSU Health Science Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"TingTing","family":"Li","sequence":"additional","affiliation":[{"name":"Louisiana Tumor Registry and Epidemiology  New Orleans Louisiana USA"},{"name":"School of Public Health LSU Health Science Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7842-1225","authenticated-orcid":false,"given":"Mei\u2010Chin","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Louisiana Tumor Registry and Epidemiology  New Orleans Louisiana USA"},{"name":"School of Public Health LSU Health Science Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Scott E.","family":"Delacroix","sequence":"additional","affiliation":[{"name":"Department of Urology LSU Health Science Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3663-5027","authenticated-orcid":false,"given":"Xiao\u2010Cheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Louisiana Tumor Registry and Epidemiology  New Orleans Louisiana USA"},{"name":"School of Public Health LSU Health Science Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Westerman","sequence":"additional","affiliation":[{"name":"Department of Urology LSU Health Science Center  New Orleans Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21731"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2017.12.015"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.06.087"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23986"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011378"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32562"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.12246"},{"key":"e_1_2_12_10_1","unstructured":"Louisiana Tumor Registry: About the Registry.2023. Accessed October 16 2023.https:\/\/sph.lsuhsc.edu\/louisiana\u2010tumor\u2010registry\/about\u2010the\u2010registry\/."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-0021"},{"key":"e_1_2_12_12_1","unstructured":"Urban and Rural. United States Census Bureau. Published September 26 2023. Accessed October 16 2023.https:\/\/www.census.gov\/programs\u2010surveys\/geography\/guidance\/geo\u2010areas\/urban\u2010rural.html."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.04.086"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.07.061"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-013-0310-1"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1011240019516"},{"key":"e_1_2_12_17_1","unstructured":"CharlsonM.Charlson Comorbidity Index (CCI).https:\/\/www.mdcalc.com\/calc\/3917\/charlson\u2010comorbidity\u2010index\u2010cci"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24701"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.12.004"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.05.008"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-020-01366-1"},{"key":"e_1_2_12_22_1","unstructured":"Percentage of Population Enrolled in Medicaid or CHIP by State.https:\/\/www.medicaid.gov\/state\u2010overviews\/scorecard\/percentage\u2010of\u2010population\u2010enrolled\u2010medicaid\u2010or\u2010chip\u2010state\/index.html."},{"key":"e_1_2_12_23_1","unstructured":"Uninsured in United States.America's Health Rankings. Accessed October 16 2023.https:\/\/www.americashealthrankings.org\/explore\/measures\/HealthInsurance"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq121"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2018.03.005"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-023-01679-x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11942"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.4236\/oalib.1107921"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2023.01.025"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-022-01553-2"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-017-0902-2"},{"key":"e_1_2_12_32_1","unstructured":"RatcliffeM BurdC HolderK FieldsA.Defining Rural at the U.S. Census Bureau. Accessed October 16 2023.https:\/\/www2.census.gov\/geo\/pdfs\/reference\/ua\/Defining_Rural.pdf. Retrieved 2nd of April2020."}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.7301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:55:45Z","timestamp":1778298945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.7301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/cam4.7301"],"URL":"https:\/\/doi.org\/10.1002\/cam4.7301","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-11-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7301"}}