{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:36:14Z","timestamp":1792701374349,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to investigate the early kinetics of interleukin 6 (IL\u20106), procalcitonin (PCT), and C\u2010reactive protein (CRP) on initial antibiotic efficacy in hematological disorder patients with febrile neutropenia (FN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 40 patients with 43 episodes of FN were enrolled and divided into initial antibiotic effective group (IAE group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924) and initial antibiotic ineffective group (IAI group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919). The levels of IL\u20106, PCT, and CRP before antibacterial treatment (T0), and 12\u2009h (T1), 24\u2009h (T2), 48\u2009h (T3), and 72\u2009h (T4) post\u2010antibacterial treatment were determined, respectively. Furthermore, the receiver operating characteristic curve (ROC) analysis was performed to evaluate the clinical value of indicators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In IAE group, the IL\u20106 levels gradually decreased from T0 to T4, and the CRP levels significantly decreased at 48 to 72\u2009h, whereas both IL\u20106 and CRP remained at high levels in the IAI group. The PCT levels in both groups increased at the early stage of anti\u2010infection (T1\u2013T2) and reached to peak at T1\u2013T2 in effective group. ROC curve analysis identified IL\u20106 as a predictive biomarker for initial antibiotic efficacy at 12, 48, and 72\u2009h after treatment, with the AUC of 0.698, 0.744, and 0.821, respectively. In addition, CRP demonstrated predictive ability of initial antibiotics against infection at 24, 48, and 72\u2009h after therapy, with the AUC of 0.724, 0.741, and 0.797, respectively. ROC curve analysis of percentage changes demonstrated that IL\u20106 percentage change showed predictive ability of antibiotic efficacy at the early stage, and both the IL\u20106 and CRP percentage changes showed the predictive ability of antibiotic efficacy 48 or 72\u2009h after antibiotics therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirmed IL\u20106 and CRP levels, and the percentage change in IL\u20106 as the biomarkers for initial antibiotic efficacy prediction in hematological disorder patients with FN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7307","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T06:24:11Z","timestamp":1720160651000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Assessment value of interleukin\u20106, procalcitonin, and C\u2010reactive protein early kinetics for initial antibiotic efficacy in patients with febrile neutropenia: A prospective study"],"prefix":"10.1002","volume":"13","author":[{"given":"Haifeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Hematology Central Hospital of Xiangtan  Xiangtan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2946-7686","authenticated-orcid":false,"given":"Zimian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology Central Hospital of Xiangtan  Xiangtan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Hematology Changsha Central Hospital  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of 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