{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:58:38Z","timestamp":1789455518161,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>En\u2010Bloc transurethral resection of bladder tumor (ERBT) was clinically used to resect non\u2010muscle\u2010invasive bladder cancer (NMIBC). However, discrepancies persist regarding the comparisons between ERBT and conventional transurethral resection of bladder tumor (cTURBT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a comprehensive search in PubMed, Embase, Web of Science, Cochrane Database of Systematic Reviews, and performed manual searches of reference lists to collect and extract data. Data evaluation was carried out using Review Manager 5.4.0, Rx64 4.1.3, and relevant packages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were nine eligible meta\u2010analyses and nine eligible RCTs in our study. NMIBC patients undergoing ERBT were significant associated with a lower rate of bladder perforation and obturator nerve reflex compared to those receiving cTURBT. Our pooled result indicated that ERBT and cTURBT required similar operation time. Regarding postoperative outcomes, ERBT demonstrated superior performance compared to cTURBT in terms of detrusor muscle presence, catheterization time, and residual tumor. ERBT exhibited a higher rate of three\u2010month recurrence\u2010free survival (RFS) compared to those receiving cTURBT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; I<jats:sup>2<\/jats:sup>\u2009=\u20090%). In bipolar subgroup, ERBT had a significant better 12\u2010month RFS than cTURBT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; I<jats:sup>2<\/jats:sup>\u2009=\u20090%). Simultaneously, the exclusion of Hybrid Knife data revealed a significant improvement in 12\u2010month RFS associated with ERBT (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05; I<jats:sup>2<\/jats:sup>\u2009=\u200950%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using a combination of umbrella review and meta\u2010analysis, we demonstrated that ERBT had better or comparable perioperative outcome and improved 3 and 12\u2009month RFS than cTURBT. We suggest that ERBT maybe a better surgical method for patients with NMIBC compared with cTURBT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7323","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T15:34:05Z","timestamp":1717169645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficiency of transurethral en\u2010bloc resection vs. conventional transurethral resection for non\u2010muscle\u2010invasive bladder cancer: An umbrella review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1943-6758","authenticated-orcid":false,"given":"Deng\u2010xiong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Urology, West China Hospital, Sichuan University  Chengdu Sichuan Province 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