{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:00:09Z","timestamp":1791414009589,"version":"4.3.3"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T00:00:00Z","timestamp":1719014400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000892","name":"Prostate Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metastatic castration\u2010resistant prostate cancer (mCRPC) is a heterogeneous disease with prognoses varying from months to years at time of castration\u2010resistant diagnosis. Optimal first\u2010line therapy for those with different prognoses is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of men in a national healthcare delivery system receiving first\u2010line therapy for mCRPC (abiraterone, enzalutamide, docetaxel, or ketoconazole) from 2010 to 2017, with follow\u2010up through 2019. Using commonly drawn prognostic labs at start of mCRPC therapy (hemoglobin, albumin, and alkaline phosphatase), we categorized men into favorable, intermediate, or poor prognostic groups depending on whether they had none, one to two, or all three laboratory values worse than designated laboratory cutoffs. We used Kaplan\u2013Meier methods to examine prostate specific antigen (PSA) progression\u2010free and overall survival (OS) according to prognostic group and first\u2010line therapy, and multivariable cox regression to determine variables associated with survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 4135 patients, median PSA progression\u2010free survival (PFS) was 6.9\u2009months (95% confidence interval [CI] 6.6\u20137.3), and median OS 18.8\u2009months (95% CI 18.0\u201319.6), ranging from 5.7\u2009months (95% CI 4.8\u20137.0) in the poor prognosis group to 31.3\u2009months (95% CI 29.7\u201332.9) in the favorable group. OS was similar regardless of initial treatment received for favorable and intermediate groups, but worse for those in the poor prognostic group who received ketoconazole (adjusted hazard ratio 2.07, 95% CI 1.2\u20133.6). PSA PFS was worse for those who received ketoconazole compared to abiraterone across all prognostic groups (favorable HR 1.76, 95% CI 1.34\u20132.31; intermediate HR 1.78, 95% CI 1.41\u20132.25; poor HR 8.01, 95% CI 2.93\u201321.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Commonly drawn labs at mCRPC treatment start may aid in predicting survival and response to therapies, potentially informing discussions with care teams. First\u2010line treatment selection impacts disease progression for all men with mCRPC regardless of prognostic group, but impacted OS only for men with poor prognosis at treatment start.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7334","type":"journal-article","created":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T04:06:31Z","timestamp":1719029191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Survival by first\u2010line therapy and prognostic group among men with metastatic castration\u2010resistant prostate cancer"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1597-5428","authenticated-orcid":false,"given":"Megan E. V.","family":"Caram","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"},{"name":"VA Health Services Research &amp; Development, Center for Clinical Management and Research VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Kumbier","sequence":"additional","affiliation":[{"name":"VA Health Services Research &amp; Development, Center for Clinical Management and Research VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-3186","authenticated-orcid":false,"given":"Phoebe A.","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"},{"name":"VA Health Services Research &amp; Development, Center for Clinical Management and Research VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Burns","sequence":"additional","affiliation":[{"name":"VA Health Services Research &amp; Development, Center for Clinical Management and Research VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1289-5476","authenticated-orcid":false,"given":"Jordan B.","family":"Sparks","sequence":"additional","affiliation":[{"name":"VA Health Services Research &amp; Development, Center for Clinical Management and Research VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3765-3393","authenticated-orcid":false,"given":"Kristian D.","family":"Stensland","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachery R.","family":"Reichert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshi J.","family":"Alumkal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent K.","family":"Hollenbeck","sequence":"additional","affiliation":[{"name":"Department of Urology Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahakn","family":"Shahinian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Medical School  Ann Arbor Michigan USA"},{"name":"Department of Urology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tsodikov","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted A.","family":"Skolarus","sequence":"additional","affiliation":[{"name":"VA Health Services Research &amp; Development, Center for Clinical Management and Research VA Ann Arbor Healthcare System  Ann Arbor Michigan USA"},{"name":"Department of Surgery, Urology Section University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040720"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64924-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2004.06.037"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21447"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.Ccr-06-2344"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33485"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209096"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405095"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt280"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2003.06.100"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.12.029"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.09.163"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/CCI.21.00030"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704174"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702900"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.19.00799"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903835"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.52.3696"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.22.02661"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2015.64.2702"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy406"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-020-00720-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0077-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22765"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.8030"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.72.1068"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7334","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.7334","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.7334","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:56:22Z","timestamp":1778298982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.7334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":28,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/cam4.7334"],"URL":"https:\/\/doi.org\/10.1002\/cam4.7334","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2024-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7334"}}