{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:05:11Z","timestamp":1790222711055,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Penile cancer (PC) is a lethal malignancy with no effective prognostic biomarker. We aim to investigate associations between trajectories of squamous cell carcinoma antigen (SCC\u2010A) and patient outcomes after chemotherapy based on paclitaxel, ifosfamid, and cisplatin (TIP) regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive AJCC staging III\/IV PC patients who received TIP chemotherapy and repeated SCC\u2010A measurements in 2014\u20132022 were analyzed. Latent class growth mixed (LCGM) models were employed to characterize patients' serum SCC\u2010A trajectories. Patient survival, and clinical and pathological tumor responses were compared. Inverse probability treatment weighting was used to adjust confounding factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty patients were included. LCGM models identified two distinct trajectories of SCC\u2010A: low\u2010stable (40%;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932) and high\u2010decline (60%;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200948). Overall survival (HR [95% CI]: 3.60 [1.23\u201310.53],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), progression\u2010free survival (HR [95% CI]: 11.33 [3.19\u201340.3],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), objective response rate (37.5% vs. 62.5%\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028), disease control rate (60.4% vs. 96.9%\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00), and pathological complete response rate (21.2% vs. 51.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) were significantly worse in the high\u2010decline arm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PC patients' SCC\u2010A change rate was associated with tumor response and patient survival after TIP chemotherapy. SCC\u2010A might assist tumor monitoring after systemic therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7353","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T09:07:20Z","timestamp":1718701640000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trajectories of squamous cell carcinoma antigen and outcomes of patients with advanced penile cancer after chemotherapy based on paclitaxel, ifosfamid, and cisplatin regimen"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-8183","authenticated-orcid":false,"given":"Nan","family":"Ma","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-6866","authenticated-orcid":false,"given":"Yi\u2010Xiang","family":"Gan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Department of Liver Surgery Sun Yat\u2010sen University Cancer Center  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010Yao","family":"Chao","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat\u2010sen University  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen\u2010Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian\u2010Da","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Department of Urology Sun Yat\u2010sen University Cancer Center  Guangzhou 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