{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:17:48Z","timestamp":1780532268896,"version":"3.54.1"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:00:00Z","timestamp":1717804800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Multiple myeloma (MM) is the leading indication of autologous hematopoietic stem cell transplantation. The aim of this study was to determine the incidence of mobilization failure and characterize the risk factors associated with poor mobilization (PM) of MM patients in novel therapies era.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of 211\u2009MM patients who received their first peripheral blood stem cells (PBSC) mobilization at our single center. The following data were collected: age, gender, clinical stage, disease status, complete blood cell count, induction regimen, CD34<jats:sup>+<\/jats:sup> cell count in peripheral blood (PB), and PBSC collections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In addition to conventional drugs, 22 (10.4%) patients received daratumumab containing induction, and 33 (15.6%) patients used plerixafor for poor mobilization (pre\u2010apheresis PB CD34<jats:sup>+<\/jats:sup> cells &lt;20\/\u03bcL). Failure of collection occurred in 24 (11.4%) patients and was correlated with low white blood cell (WBC), \u22653\u2009cycles of lenalidomide treatment before mobilization, steady\u2010state mobilization and nouse of plerixafor are associated with mobilization failure. Daratumumab\u2010based induction treatment \u22652 courses, albumin &gt;41\u2009g\/L before mobilization, and steady\u2010state mobilization were risk factors for PM in subgroups of patients treated with lenalidomide for &lt;3 courses. In addition, Hepatitis B virus infection at baseline, thalassemia and measurable residual disease positivity were recognized as predictive factors for PM in subset of chemo\u2010mobilization patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In addition to some well\u2010recognized risk factors, baseline WBC count and daratumumab exposure \u22652 courses before mobilization were revealed as the predictive factors of mobilization failure, providing consultation for preemptive use of plerixafor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7356","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T09:40:02Z","timestamp":1717839602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictive factors for peripheral blood stem cell mobilization in multiple myeloma in the era of novel therapies: A single\u2010center 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