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We share our department's experience regarding patients treated with this regimen in real\u2010world clinical settings, detailing outcomes related to short\u2010term toxicity and efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A descriptive observational study was conducted on 160 patients diagnosed with breast cancer. Between July 2020 and December 2021, patients underwent conservative surgery followed by a regimen of 26\u2009Gy administered in five daily fractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 64\u2009years (range: 43\u201383), with 82 patients (51.3%) treated for left\u2010sided breast cancer, 77 patients (48.1%) for right\u2010sided breast cancer, and 1 instance (0.6%) of bilateral breast cancer. Of these, 66 patients had pT1c (41.3%), 70.6% were infiltrative ductal carcinomas, and 11.3% were ductal carcinoma in\u00a0situ. Most tumours exhibited intermediate grade (41.9%), were hormone receptor positive (81.3%), had low Ki\u201067 (Ki\u201067\u2009&lt;\u200920%; 51.9%) and were Her 2 negative (85%). The majority of surgical margins were negative (99.4%). Among the patients, 72.5% received hormonotherapy, and 23.8% received chemotherapy. Additionally, 26 patients (16.3%) received an additional tumour boost following whole breast irradiation (WHBI) of 10\u2009Gy administered in five sessions of 2\u2009Gy over a week. The median planning target volume (PTV) was 899\u2009cm<jats:sup>3<\/jats:sup> (range: 110\u20132509\u2009cm<jats:sup>3<\/jats:sup>). Early toxicity was primarily grade I radiodermatitis, affecting 117 patients (73.1%). During a median follow\u2010up of 15\u2009months (range: 3.9\u201328.77), only one patient experienced a local relapse, which required mastectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The implementation of this highly hypofractionated regimen in early\u2010stage breast cancer appears feasible and demonstrates minimal early toxicity. However, a more extended follow\u2010up duration would be required to evaluate long\u2010term toxicity and efficacy accurately.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7367","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T06:39:00Z","timestamp":1720247940000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrahypofractionation in postoperative radiotherapy for breast cancer: A single\u2010institution retrospective cohort series"],"prefix":"10.1002","volume":"13","author":[{"given":"Angel","family":"Calvo\u00a0Tudela","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5237-179X","authenticated-orcid":false,"given":"Mar\u00eda Jes\u00fas","family":"Garc\u00eda\u00a0Anaya","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Segado\u00a0Guillot","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Martin\u00a0Romero","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Lorca\u00a0Oc\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Medina\u00a0Carmona","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"G\u00f3mez\u2010Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"},{"name":"Malaga Biomedical Research Institute  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Garc\u00eda\u00a0R\u00edos","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Virgen de la Victoria University Hospital  Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61629-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70699-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906260"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70386-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.2666"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2018.10.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01363"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2018.01.012"},{"key":"e_1_2_7_10_1","volume-title":"Early and Locally Advanced Breast Cancer: Diagnosis and Management","year":"2018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282202"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)02133-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30813-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60348-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02750"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30932-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21388"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.3031"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2014.11.030"},{"key":"#cr-split#-e_1_2_7_20_1.1","unstructured":"National Cancer Institute National Institutes of Health US Department of Health and Human Services.Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0. 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