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We investigated the outcomes of AML patients with monocytic differentiation who were treated with frontline VEN\/HMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 155 patients with newly diagnosed AML treated with frontline VEN\/HMA were enrolled in the study. Monocyte\u2010like AML was identified by flow cytometry with typical expression of monocytic markers, and M5 was identified according to French, American, and British category. We compared the outcomes of patients with different characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of complete remission (CR) and CR with incomplete recovery of blood counts (CRi), progression\u2010free survival (PFS), and overall survival (OS) in monocyte\u2010like AML were inferior to those in nonmonocyte\u2010like AML (CR\/CRi rates, 26.7% vs. 80.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; median PFS, 2.1 vs. 8.8\u2009months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; median OS, 9.2 vs. 19\u2009months, <jats:italic>p<\/jats:italic>\u2009=\u20090.013). CR\/CRi rate in M5 was lower than that in non\u2010M5 (60.7% vs. 75.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.049). Multivariate analyses showed that monocyte\u2010like AML was associated with lower odds of CR\/CRi and higher risk of progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggested that newly diagnosed AML with a monocytic immunophenotype had a poor prognosis with VEN\/HMA treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7378","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T09:31:20Z","timestamp":1721381480000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of monocytic differentiation on acute myeloid leukemia patients treated with venetoclax and hypomethylating agents"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0919-7239","authenticated-orcid":false,"given":"Dian","family":"Jin","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center, The First 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