{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:11:58Z","timestamp":1778299918242,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nivolumab was approved for the treatment of advanced gastric cancer in 2017 in Japan. The aim of this study was to assess the impact of nivolumab in a real\u2010world clinical setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010institutional retrospective study included patients with advanced gastric or esophagogastric junction adenocarcinoma and a history of first\u2010line chemotherapy with platinum\u2010based doublet or triplet regimens between 2010 and 2020. To assess the impact of nivolumab on survival, the patients were divided based on the year of nivolumab approval into a pre\u20102017 (2010\u20132016) group and a post\u20102017 (2017\u20132020) group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From a total of 1918 patients, 1093 were excluded. There were 533 patients in the pre\u20102017 group and 292 in the post\u20102017 group. Immune checkpoint inhibitors were used significantly more often in the post\u20102017 group than in the pre\u20102017 group (8.6% vs. 47.9%). Median overall survival was significantly longer in the post\u20102017 group (16.9 vs. 13.9\u2009months; hazard ratio [HR] 0.75, 95% confidence interval [CI] 0.63\u20130.90;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The proportion of patients transitioning to third\u2010line treatment was higher in the post\u20102017 group than in the pre\u20102017 group (56.3% vs. 43.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Median survival outcomes following progression on second\u2010line treatment were significantly longer in the post\u20102017 group (4.3 vs. 3.2\u2009months; HR 0.70, 95% CI 0.57\u20130.86;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proportion of patients transitioning to third\u2010line treatment and survival outcomes following progression on second\u2010line treatment have improved since the approval of nivolumab. This drug might help to prolong overall survival in real\u2010world practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7401","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:35:16Z","timestamp":1718868916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of immune checkpoint inhibitors on survival outcomes in advanced gastric cancer in Japan: A real\u2010world analysis"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2898-4860","authenticated-orcid":false,"given":"Toru","family":"Kadono","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"},{"name":"Cancer Chemotherapy Center Osaka Medical and Pharmaceutical University  Takatsuki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Iwasa","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiharu","family":"Hirose","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Okita","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8922-5227","authenticated-orcid":false,"given":"Hirokazu","family":"Shoji","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","unstructured":"Cancer Statistics in Japan\u20142023. 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